The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. [5] This enzyme is responsible for phosphorylating other proteins and …

2024年12月25日 · PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PRKACA include Pigmented Nodular …

PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are …

蛋白激酶 A 对蛋白质的 cAMP 依赖性磷酸化对许多细胞过程很重要，包括分化、增殖和凋亡。 由体细胞突变或包括该基因的区域的基因组重复引起的该基因的组成性激活与肾上腺皮质的增生 …

2024年4月15日 · 山西医科大学Ji-Min Cao/De-Ping Wang教授团队在本刊发表了题为“Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer …

PRKACA，cAMP-dependent protein kinase catalytic subunit alpha,别名PKCA1、Cs-PKA等。PRKACA是蛋白激酶A（PKA）的α催化亚基，PKA是一种由cAMP激活的丝氨酸/苏氨酸蛋白 …

2015年5月20日 · In this review, we summarize the current understanding of the involvement of PRKACA in adrenocortical tumorigenesis, and our understanding of PKA's role in …

2016年2月15日 · This article focuses on the discovery, structure, cellular location and physiological effects of the catalytic subunit alpha of protein kinase A (encoded by the gene …

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members …

2024年9月19日 · This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its …