今天我们要讲的主角是编码了 NHEJ 通路中关键蛋白 DNA-PKcs 的 Prkdc基因 。 Prkdc编码的DNA-PKcs DNA依赖性蛋白激酶（DNA-dependent protein kinase, DNA-PK）是一个由DNA激活的丝氨酸/苏氨酸蛋白激酶，大量表达在几乎所有哺乳动物的细胞中。

DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and has a number of other DNA housekeeping functions. [5] . In humans it is encoded by …

2024年12月25日 · PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit) is a Protein Coding gene. Diseases associated with PRKDC include Immunodeficiency 26 With Or Without Neurologic Abnormalities and Severe Combined Immunodeficiency. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and miRNA regulation of DNA damage response.

2021年10月26日 · The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also closely related to the establishment of central immune tolerance and the maintenance of ch …

2021年10月26日 · Here, we discuss and review the structure and mechanism of action of PRKDC and DNA-PKcs and their relationship with cancer. The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein.

Finally, we found that knockout PRKDC or DNA-PK inhibitor (PRKDC encodes the catalytic subunit of DNA-dependent protein kinase) enhanced the efficacy of the anti-programmed cell death protein one pathway monoclonal antibody in the CT26 animal model.

2022年7月8日 · The PRKDC expression level was shown a positive correlation with tumor-infiltrating immune cells. PRKDC high expression cohorts were enriched in "cell cycle" "oocyte meiosis" and "RNA-degradation" signaling pathways.

该基因编码 DNA 依赖性蛋白激酶 (DNA-PK) 的催化亚基。 它与 DNA 双链断裂修复和重组中的 Ku70/Ku80 异二聚体蛋白一起发挥作用。 编码的蛋白质是 PI3/PI4 激酶家族的成员。 [RefSeq 提供，2010 年 7 月] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination.

2022年8月9日 · 本研究团队通过采用CRISPR/Cas9基因编辑技术，构建了NOD背景的Prkdc和Il2rg双敲除免疫缺陷小鼠，命名为NYG小鼠，为肿瘤研究和药物评估提供了良好的PDX模型。

由该基因编码的蛋白质是丝氨酸和苏氨酸特异性蛋白激酶的蛋白激酶 C 家族的成员。 编码的蛋白质被甘油二酯激活，既是肿瘤抑制因子又是细胞周期进程的正调节因子。 此外，这种蛋白质可以正向或负向调节细胞凋亡。 该基因的缺陷是自身免疫性淋巴增生综合征的一个原因。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases.