2024年12月25日 · PRODH (Proline Dehydrogenase 1) is a Protein Coding gene. Diseases associated with PRODH include Hyperprolinemia, Type I and Schizophrenia 4. Among its related pathways are superpathway of L-citrulline metabolism and Proline catabolism. Gene Ontology (GO) annotations related to this gene include FAD binding and proline dehydrogenase activity.

Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix (ECM), and the degradation of proline through the proline cycle initiated by proline oxidase (PRODH), a …

The PRODH gene provides instructions for producing the enzyme proline dehydrogenase (also known as proline oxidase), which is found primarily in the brain, lung, and muscle. Within cells of these organs, this enzyme functions in energy-producing structures called mitochondria.

关于 prodh Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:18,912,781-18,936,553 (from NCBI) This gene has 15 transcripts (splice variants), 261 orthologues, 2 paralogues and is associated with 3 phenotypes.

Proline Dehydrogenase (PRODH) expression is reduced in human with Heart Failure. PRODH appears to be crucial to sustain normal mitochondrial function and maintenance of ATP levels in human cardiomyocytes in a hypoxic environment, as well as for redox homeostasis in both normoxic and hypoxic conditions.

2012年1月1日 · Proline dehydrogenase (ProDH), also called proline oxidase (POX), is a universal enzyme in living organisms. It catalyzes the oxidation of L-proline to delta1-pyrroline-5-carboxylate leading to the release of electrons, which can be transferred to either electron transfer systems or to molecular oxy …

2008年9月5日 · Proline dehydrogenase (EC 1.5.5.2) is involved in the degradation of the amino acid proline. It catalyzes the conversion of proline to pyrroline-5-carboxylate, or P5C.

2024年12月21日 · Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene …

Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; forelimb bud; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1).

该基因类似于脯氨酸脱氢酶 (氧化酶) 1，一种催化脯氨酸分解代谢第一步的线粒体酶。 [RefSeq 提供，2017 年 1 月] The protein encoded by this gene catalyzes the first step in the catabolism of trans-4-hydroxy-L-proline, an amino acid derivative …