Profilin is an actin-binding protein involved in the dynamic turnover and reconstruction of the actin cytoskeleton. [1] It is found in most eukaryotic organisms. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes.

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Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription.

Profilins are small actin-binding proteins found in eukaryotes and certain viruses that are involved in cell development, cytokinesis, membrane trafficking, and cell motility. Originally identified as an actin sequestering/binding protein, profilin ...

Profilin is a small protein found in all eukaryotic cells that regulates the cytoskeleton and binds to actin. In the context of allergies, it is an allergen found in flowering plants, pollens, and certain foods, causing reactions in a subset of individuals who are sensitized to it.

2020年7月20日 · A new study reports that the actin-monomer-binding protein profilin 1 dictates protrusion character at the cell edge. These findings help explain how distinct, tunable actin polymerization pathways collaborate to form higher-order cellular structures.

2020年7月13日 · Profilin is a ubiquitously expressed protein well known as a key regulator of actin polymerisation. The actin cytoskeleton is involved in almost all cellular processes including motility, endocytosis, metabolism, signal transduction and gene transcription.

Profilin 1 vs. Profilin 2a – From Proteins, Mice and Chicken. To discuss the functional diversity of PFN1 and PFN2a, we here elaborate their binding properties to different ligands as well as the phenotypes, caused by manipulating PFN1 and/or PFN2a in cells and animals.

Profilin is an actin binding protein that can both inhibit and enhance actin polymerization through a variety of molecular mechanisms, including inhibition by sequestering monomeric G-actin, enhancement by catalyzing the exchange of ADP for ATP to produce ATP-actin that can then be added to the barbed end of an elongating filament, as well as ...

Profilin is a ubiquitous cytosolic protein and was one of the first identified actin-binding proteins. Initial studies suggested that its main function was to sequester actin monomers in a 1:1 complex and then release actin in response to downstream cellular signals such as an increase in phosphatidylinositol (4,5)-bisphosphate (PIP 2 ) [ 1 , 2 ].