Progastrin is an 80-amino acid intracellular protein and the precursor of gastrin, a gastrointestinal hormone produced by G cells in the gastric antrum. [1] The main function of gastrin is to …

It has been shown recently that the two largest alpha-carboxyamidated progastrin products are gastrin-71 and gastrin-52. Human gastrin-52 has now been synthesized, and the effect on …

In humans, progastrin is processed to six bioactive gastrin's (gastrin -71, -52, -34, -17, -14, and -6) of which the five longest circulate in both a tyrosyl O-sulfated and a non-sulfated form (Fig. …

Progastrin is a precursor molecule of gastrin, synthesized as pre-progastrin, converted to progastrin after cleavage, and transformed into amidated gastrin via biosynthetic …

2012年12月7日 · Progastrin may exert greater proliferative effects than amidated gastrins on normal and tumor cells (CRC, pancreatic) in culture[28,86] and also has an antiapoptotic …

Secretion of progastrin is a signature event of early malignant transformation in the colon. In the healthy epithelium, progastrin is produced by a subset of enteroendocrine cells expressing …

ProGRP偏高一般指检测结果大于50pg/mL，可能由于样本污染、操作失误所致，也可提示小细胞肺癌、甲状腺髓样癌等恶性肿瘤，以及泌尿系统、呼吸系统等良性疾病。 样本污染、操作失 …

In this study, we examined the effects of N‐terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1‐35 were infused …

The kinetics and metabolism in various organs of three bioactive products of progastrin, the small sulfated and nonsulfated gastrin-6 and the large nonsulfated gastrin-52, were examined during …

Progastrin is the precursor of the gastrointestinal hormone, gastrin, which regulates gastric mucosal growth and gastric acid secretion. As indicated in Figures 1 and 2 , the maturation of …