Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. [5] [6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins. [7]

2024年12月25日 · PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include Lymphangioma and Generalized Lymphatic Anomaly. Among its related pathways are Angiogenesis (CST) and PTF1A related regulatory pathway.

2025年2月13日 · We validated hepatocyte-specific candidates using reprogramming, revealing that prospero homeobox protein 1 (PROX1) enhanced hepatocyte identity by direct repression of alternative fate master...

2022年11月24日 · Here, we identify Prospero-related homeobox 1 (PROX1) as a crucial factor for tumour metabolic plasticity. Notably, PROX1 is reduced by glucose starvation or AMP-activated protein kinase (AMPK)...

2025年2月17日 · 这项研究颠覆了传统认知——过去认为细胞身份主要依赖激活自身基因，而prox1机制证明持续压制"异心基因"同等重要。当研究人员在小鼠中敲除prox1，62%的肝细胞癌竟转变成恶性度更高的胆管癌；反之，过表达prox1能使晚期肿瘤细胞"浪子回头"，恢复肝细胞特征。

2018年6月22日 · Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprotease involved in angiogenesis and cancer invasion, by binding and suppressing the activity of MMP14 promoter. Prox1...

2024年8月10日 · In this study, we identified PROX1 as a driver of neuroendocrine plasticity in PCa, responsible for promoting liver metastases. Mechanistically, anti-androgen therapy alleviates transcriptional inhibition of PROX1.

2023年6月27日 · Here, we show that enhanced autolysosomal activity mediated by mTORC1 inhibition induces PROX1 expression and that PROX1 induction in turn inhibits NOX1-mTORC1 activation. CDX2, identified as a transcriptional activator of NOX1, mediates PROX1-dependent NOX1 inhibition.

该基因编码的蛋白质是同源框转录因子家族的成员。 该家族的成员包含一个同源框结构域，该结构域由结合 DNA 和 RNA 的 60 个氨基酸的螺旋-转角-螺旋结构组成。 由该基因编码的蛋白质在脊椎动物中是保守的，并且可能在发育过程中发挥重要作用。 据报道，这种蛋白质水平的改变发生在不同器官的癌症中，例如结肠癌、脑癌、血液癌、乳腺癌、胰腺癌、肝癌和食道癌。 可变剪接导致多个转录本变体。 [RefSeq 提供，2012 年 7 月] The protein encoded by this gene is a member …

摘要：同源异型蛋白Prox1 (Prospero homeobox1)是果蝇Prospero蛋白在脊椎动物中的同源物，它在眼球、视网膜、肝、胰以及淋巴管等器官和细胞类型的形成过程中起着重要的作用。 目前，对Prox1作用机制的了解还处在起步阶段。 已有的研究结果显示Prox1能与核受体LRH-1、HNF4α相互作用并抑制靶基因如CYP7A1和SHP的表达，然而Prox1作为辅抑制因子的作用机制还不清楚。 另有研究结果显示Prox1可能在肿瘤发生和转移以及胆汁酸代谢调控方面发挥作用。 本研究分 …