2014年8月14日 · PS19 transgenic mice express mutant human microtubule-associated protein tau, MAPT, driven by the mouse prion protein (Prnp) promoter. The transgene encodes the disease-associated P301S mutation and includes four microtubule-binding domains and one N-terminal insert (4R/1N).

2021年2月10日 · PS19 mice exhibited significant increases in synaptic tau protein levels and mean dendritic spine head diameter with age. This suggests that CA1 pyramidal neurons in PS19 mice may undergo spine remodeling in response to tau accumulation and age.

We confirmed prevention of further neuronal loss as measured by NeuN-positive cell counts in the hippocampus after treatment with Tau ASO-12 in aged PS19 mice (DAPI and NeuN dual-positive cells: P = 0.005, one-way ANOVA, Sidak post hoc analysis; cell size: P < 0.0001, one-way ANOVA, Sidak post hoc analysis).

2018年9月19日 · To address this key open question, we selected the transgenic mouse line MAPTP301SPS19 (hereafter PS19), which—under the regulation of the mouse prion promoter—expresses high levels of mutant...

2024年12月23日 · To test this, we bred the ISR models to the PS19 tauopathy model to generate PS19iPKR and PS19Eif2 A mice. In PS19iPKR mice, ISR induction in microglia by intermittent ASV treatment significantly increased hyperphosphorylated tau levels, specifically within neurons, while its occlusion in PS19 Eif2 A mice significantly decreased them ( Figures ...

PS19转基因小鼠表达突变的人类微管相关蛋白tau、MAPT，由小鼠朊蛋白 (Prnp)启动子驱动。 该转基因体系编码与疾病相关的P301S突变，并包括四个微管结合结构域和一个N末端插入 (4R/1N)。

2024年11月15日 · In the PS19 transgenic mouse, weak increase of glial fibrillary acidic protein (GFAP), a marker for astroglia cells, could be detected throughout brain at 3-month-old age, while marked increase of GFAP was observed in 6 month old PS19 mice 32. We then examined the ability of ANKHD1 to suppress glial activation caused by the mutant Tau protein ...

2023年8月25日 · PS19小鼠表达由小鼠朊病毒启动子驱动的具有P301S突变的人1N4R-tau。 PS19小鼠的特征是在神经原纤维缠结病理和神经元丢失之前早期突触丢失和小胶质细胞激活。

We confirmed prevention of further neuronal loss as measured by NeuN positive cell counts in the hippocampus following treatment with Tau ASO-12 in aged PS19 mice (DAPI and NeuN dual positive cells: p=0.005 one-way ANOVA, Sidak post-hoc; cell size: p<0.0001 one-way ANOVA, Sidak post-hoc).

2023年2月20日 · To further confirm its specificity in 10-month-old PS19-fE mice, we immunostained for Cre recombinase in multiple APOE-expressing cell types, including neurons (NeuN), astrocytes (GFAP),...