2024年12月25日 · PSAT1 (Phosphoserine Aminotransferase 1) is a Protein Coding gene. Diseases associated with PSAT1 include Neu-Laxova Syndrome 2 and Phosphoserine Aminotransferase Deficiency. Among its related pathways are serine and glycine biosynthesis and One-carbon metabolism and related pathways.

Phosphoserine aminotransferase (PSA) also known as phosphohydroxythreonine aminotransferase (PSAT) is an enzyme that in humans is encoded by the PSAT1 gene. [5] The protein encoded by this gene is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila.

2023年2月15日 · Our finding revealed a non-enzymatic role of PSAT1, in which PSAT1 might be essential for metabolic rerouting during tumor cell metastasis, and targeting PSAT1 may hold the potential to benefit...

2025年2月9日 · PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells. Overexpression of PSAT1 is Correlated with Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer.

2024年8月27日 · Mechanistically, we find that phosphoserine aminotransferase 1 (PSAT1) has a unique capacity for sustained α-KG production when glutamate is depleted. Breast cancer cells with resistance to...

Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways critical for cell proliferation, survival, migration and epigenetics, such as glycolysis, de novo serine synthesis, citric acid cycle …

2024年10月21日 · Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis. However, little is known about the mechanisms underlying PSAT1 degradation. We found that acetylation was...

PSAT1 is the protein-coding gene of phosphoserine aminotransferase, which catalyzes serine biosynthesis. PSAT1 is overexpressed in colon cancers where it contributes to cell proliferation and chemoresistance, which result in a poor prognosis .

2017年12月8日 · Background: A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrogen receptor (ER)-negative breast cancer.

2020年6月11日 · Down-regulation of PSAT1 inhibits the clonogenicity, cell cycle and promotes apoptosis. PSAT1 expression increases the proportion of GSH and reduced nicotinamide adenine dinucleotide phosphate (NADPH) in EOC cells, increasing oxidative stress tolerance.