2023年8月1日 · We review recent findings on nonvesicular transport of PS by lipid transfer proteins (LTPs) at membrane contact sites, on PS flip-flop between membrane leaflets by flippases and scramblases, and on PS nanoclustering at the PM.

In this review, we discuss how combined action of PS biosynthesis enzymes in the endoplasmic reticulum (ER), lipid transfer proteins (LTPs) acting within membrane contact sites (MCS) between the ER and other compartments, and lipid flippases and scramblases that mediate PS flip-flop between membrane leaflets controls the cellular distribution ...

2023年12月8日 · We purified correctly folded human VDAC2 after producing it recombinantly in E. coli (Fig. S 2) and reconstituted it into large unilamellar vesicles composed mainly of PC with a trace quantity of...

Phosphatidylserine decarboxylase 1 (Psd1p) belongs to a family of decarboxylases that contain pyruvoyl prosthetic groups necessary for the decarboxylation of their substrate (van Poelje and Snell, 1990). PS decarboxylases and their role in phospholipid metabolism have been evolutionarily conserved from bacteria to humans (Schuiki and Daum, 2009).

2023年12月8日 · These observations suggested that VDAC1 - and perhaps other VDAC isoforms - may be able to facilitate rapid phospholipid flip-flop, thereby providing the scramblase activity needed to move lipids across the OMM for mitochondrial function.

在计算机中，有时候我们更想让输入在 某一时刻 产生变化，我们需要两个东西来实现：1）时钟（The clock）和2）触发器（The Flip-Flops）。 首先来了解一下时钟clock，时钟就是一系列的方波信号，如下图所示。 我们将时钟信号从0到1变化的部分称为上升沿（The rising edge），将从1到0变化的部分称为下降沿（The falling edge）。 我们希望计算机中的控制，比如将数据写入锁存器发生在上升或下降沿，这种输入随着输出变化的方式称为 边沿触发 （Edge-sensitive，or …

2021年8月10日 · 本章将理解 RS/D 锁存器的概念，了解 RS/D/JK 触发器的概念，使用 Verilog 实现各种锁存器 (Latch) 和翻转器 (Flip-Flop)，并通过 FPGA 验证用 Verilog 的实现。 基础—— ( 5 ) D Flip - Flop ( D 触发器 )

本章将理解 RS/D 锁存器的概念，了解 RS/D/JK 触发器的概念，使用 Verilog 实现各种锁存器 (Latch) 和翻转器 (Flip-Flop)，并通过 FPGA 验证用 Verilog 的实现。 锁存器 （ Latch ） 与 触发器 （ Flip - Flop ）AND寄存器（Register）（7）

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