
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes …
2021年8月2日 · These results indicate that rHMGB1 promotes NRF2 independent mitochondrial fusion via CXCR4/PSMB5 pathway-mediated Drp1 proteolysis. rHMGB1 may influence mitochondrial and endothelial function through this effect on mitochondrial dynamics.
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes …
2021年8月2日 · Schematic depiction of rHMGB1-induced mitochondrial fusion and the underlying mechanism. rHMGB1 combines and activates the membrane receptor CXCR4, then upregulates the expression of PSMB5 to increase the activity of 20S proteasome, leads to degradation of mitochondrial fission protein Drp1, and results in mitochondrial hyperfusion. rHMGB1 ...
Potential Protective and Therapeutic Roles of the Nrf2 Pathway in ...
Proteasome beta 5 (PSMB5), which can degrade many aberrant and denatured intracellular proteins as well as functional proteins, is mediated by the Nrf2-ARE pathway in many cell types.
1,4-dihydropyridine Derivatives Increase mRNA Expression of
2021年6月28日 · Proteasome gene expression is triggered by the nuclear respiratory factor 1 (Nrf1). This transcription factor is, in turn, regulated by the mammalian target of rapamycin complex 1 (mTORC1) and a feedback mechanism compensating proteasome dysfunction .
Induction of 26S proteasome subunit PSMB5 by the
2006年7月14日 · Activation of the Psmb5 promoter through the Nrf2-ARE pathway following 3-MC incubation is demonstrating that this system can be regulated by environmental stimuli. Dynamic changes of proteasome expression upon exposure to exogenous chemicals may be an important part of the cellular adaptive response against oxidative stress to promote cell ...
The promoter of PSMB5 is activated by sulforaphane treatment or …
Murine PSMB5 promoter constructs (A) and luciferase activities derived from these truncated promoters following treatment with sulforaphane (10 M) or cotransfection of an Nrf2 expression plasmid...
PSMB5 Gene - GeneCards | PSB5 Protein | PSB5 Antibody
2024年12月25日 · PSMB5 (Proteasome 20S Subunit Beta 5) is a Protein Coding gene. Diseases associated with PSMB5 include Cystic Fibrosis and Parkinson's Disease. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and CDK-mediated phosphorylation and removal of Cdc6.
患者基因检测结果,我们发现6例(2.1%)患者在耐 药后出现了PSMB5基因突变,其中4例患者获得了 部分缓解(partial response,PR)疗效,2例患者疗 效为疾病稳定(stable disease,SD)。上述6 例 PSMB5突变中,4例为p.A79T,2例为p.M104I。 1.2 DNA/RNA提取与测序
Binding of Nrf2 to PSMB5 promoter in intact cells. (A) Chromatin ...
ARE-containing promoter regions from PSMB5 and the GSTA1 promoter were detected in Nrf2 immunoprecipitants obtained from sulforaphane-treated wild-type cells.
Ilexgenin A inhibits mitochondrial fission and promote Drp1 ... - PubMed
These results demonstrated that IA could promote PSMB5 expression in an Nrf2-dependent manner, resulting in the suppression of mitochondrial fission, and thus improve endothelial dysfunction. These findings laid a foundation to the future development of IA as an agent to the prevention and treatment of AS.
Review Trash Talk: Mammalian Proteasome Regulation at the ...
2021年2月1日 · Immunoproteasome expression can be increased by interferon regulatory factor 1 (IRF1) after its expression is upregulated by the interferon gamma (IFNγ)-induced Stat1 transcription factor (left panel). Upregulation of the PSMB 1–7 genes by epidermal growth factor (EGF)-induced STAT3 can play a role in oncogenic proliferation (right panel ...
Induction of 26S proteasome subunit PSMB5 by the bifunctional …
2006年7月14日 · Collectively, these results indicate that expression of proteasome subunit PSMB5 is modulated by bifunctional enzyme inducers in a manner independent of the AhR/Arnt-XRE pathway but dependent upon the Nrf2-ARE pathway.
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes …
2021年8月3日 · These results indicate that rHMGB1 promotes NRF2 independent mitochondrial fusion via CXCR4/PSMB5 pathway-mediated Drp1 proteolysis. rHMGB1 may influence mitochondrial and endothelial function...
突变型PSMB5调节免疫微环境诱导非小细胞肺癌抗PD-1免疫治疗 …
下一项: 能量限制抑制肿瘤血管生成对低剂量化疗的增敏效果与机制研究. 突变型PSMB5调节免疫微环境诱导非小细胞肺癌抗PD-1免疫治疗耐药的机制研究(国科金青年科学基金项目)。
The promoter of PSMB5 is regulated by the Nrf2-ARE pathway. (A ...
(A) Luciferase activity driven by the proximal PSMB5 promoter ( Ϫ 1.1kb-luc) following treatment with antioxidants in wild-type and nrf2 -disrupted cells. BHT, butylhydroxytoluene; EQ,...
PSMB5 plays a dual role in cancer development and ... - PubMed
2017年11月1日 · Based on our bioinformatics analysis, we hypothesized that PSMB5 contained immunosuppressive and oncogenic characteristics. To study the effects of PSMB5 on the cancer cell and macrophage in vitro, we silenced PSMB5 expression with shRNA in THP-1 monocytes and MDA-MB-231 cells respectively.
Molecular basis of bortezomib resistance: proteasome subunit β5 (PSMB5 ...
2008年9月15日 · Study of the molecular mechanism of bortezomib resistance in these cells revealed (1) an Ala49Thr mutation residing in a highly conserved bortezomib-binding pocket in the proteasome β5-subunit (PSMB5) protein, (2) a dramatic overexpression (up to 60-fold) of PSMB5 protein but not of other proteasome subunits including PSMB6, PSMB7, and PSMA7 ...
PSMB5 Rabbit mAb - Selleck中国
psmb5参与抗原呈递和氧化应激,与b细胞、cd4+t细胞、cd8+t细胞、树突状细胞、巨噬细胞和中性粒细胞的丰度密切相关。psmb5可作为hcc诊断和预后的生物标志物。此外,psmb5在多种癌症中起促癌作用,包括乳腺癌、食管鳞状细胞癌和前列腺癌。
Proteasome Subunits Differentially Control Myeloma Cell …
Depleting PSMB6 prevented splicing of the major catalytic subunits PSMB5, PSMB7, PSMB8, and PSMB10; however, PSMB6 engineered without splicing function or catalytic activity, also restored viability, inferring the contribution of PSMB6 to proteasome structure to be more important than functional activity.
Psmb5 Mouse qPCR Primer Pair (NM_011186)
A ready-to-use mix for SYBR Green qPCR, containing ROX reference and suitable for all qPCR instruments without adjusting the concentration of ROX. 1 vial of lyophilized qSTAR qPCR primer mix (1 nmol each primer, sufficient for 200 reactions). Before use, reconstitute the primer mix in 200 µl dH2O to make a final concentration of 10 µM.