2006年9月1日 · We demonstrated that PSPC1, NONO, and SFPQ are coexpressed in Sertoli cell line TTE3 and interact reciprocally. The effect of the DBHS-containing proteins on the transcriptional activity was assessed using the construct containing androgen-responsive elements followed by a luciferase gene.

2016年4月15日 · Sertoli cells contain all heterodimer combinations (PSPC1/SFPQ, SFPQ/NONO and PSPC1/NONO), whereas HeLa cells predominantly contain SFPQ/NONO and PSPC1/NONO. Different dimers may have different cell-type specific functions, as DBHS proteins can functionally compensate for each other in some biological scenarios, but not others.

2025年2月9日 · PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2. Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility.

2024年12月25日 · Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).

2016年5月19日 · Herein, we present a coherent picture of DBHS proteins, integrating recent structural insights on dimerization, nucleic acid binding modalities and oligomerization propensity with biological function.

2024年11月1日 · Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

2024年12月25日 · SFPQ (Splicing Factor Proline And Glutamine Rich) is a Protein Coding gene. Diseases associated with SFPQ include Renal Cell Carcinoma With Mit Translocations and Renal Cell Carcinoma. Among its related pathways are Signaling by …

These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins.

研究发现，PSPC1参与细胞核内RNA滞留、DNA甲基化修饰和细胞周期调控，还可能在神经退行性疾病、肥胖、癌症的发生、发展以及预后方面发挥重要作用。 本文将对PSPC1的结构和功能，尤其是与DNA损伤修复相关的研究进展进行综述。 中图分类号: 徐贤荣, 杨军. 旁斑蛋白组成成分1的结构与生物学功能研究进展 [J]. 癌变·畸变·突变, 2019, 31 (6): 488-491. 导出引用管理器 EndNote | Reference Manager | ProCite | BibTeX | RefWorks. 链接本文: …

2018年4月4日 · Here we report the crystal structure of a SFPQ/PSPC1 heterodimer to 2.3-Å resolution and analyzed the subtle structural differences between the SFPQ/PSPC1 heterodimer and the previously characterized SFPQ homodimer.