2024年12月25日 · PTGDS (Prostaglandin D2 Synthase) is a Protein Coding gene. Diseases associated with PTGDS include Intracranial Hypotension and Normal Pressure Hydrocephalus. Among its related pathways are Fatty acid metabolism and …

2021年11月6日 · Here, we aimed to explore the expression and function of PTGDS in diffuse large B-cell lymphoma (DLBCL), especially the potential role of PTGDS inhibitor, AT56, in lymphoma therapy....

β-Trace protein (BTP), also known as lipocalin prostaglandin D2 synthase (L-PGDS; encoded by the PTGDS gene), is a low-molecular-weight glycoprotein and an emerging novel marker of glomerular filtration rate.

2015年5月12日 · In this study we investigated whether OPC express neuromodulatory factors, typically synthesized by other CNS cell types. Our results show that OPC express two well-characterized neuromodulatory proteins: Prostaglandin D2 synthase (PTGDS) and neuronal Pentraxin 2 (Nptx2/Narp).

View mouse Ptgds Chr2:25356721-25360058 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

2023年11月23日 · PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain.

2024年9月17日 · Go to Variation Viewer for PTGDS variants Summary The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2).

Further validation demonstrated that PTGDS was significantly downregulated in the EC group compared with the atypical hyperplasia and normal endometrial groups, and its low expression was an independent risk factor for worse prognosis of EC.

2025年2月8日 · Ptgds is targeted and repressed by the CUL4B/PRC2 complex. Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP (+), and NADH. Prostaglandin D2 synthase is a novel MR target gene in adipocytes.

2016年9月14日 · The protein encoded by the PTGDS gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system.