2024年12月25日 · PTHLH (Parathyroid Hormone Like Hormone) is a Protein Coding gene. Diseases associated with PTHLH include Brachydactyly, Type E2 and Brachydactyly, Type E1. Among its related pathways are Endochondral ossification with skeletal dysplasias and GPCR downstream signalling.

A novel heterozygous mutation in PTHLH gene was identified in a Chinese pedigree with brachydactyly type E. PTHLH/PTHrP could play a role in the pathogenesis of oral squamous cell carcinoma by affecting cell proliferation and cell cycle. PTHrP regulates Caco-2 cell proliferation via several signaling pathways.

2017年1月25日 · Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However,...

Parathyroid hormone-related protein (PTHrP) is a proteinaceous hormone and a member of the parathyroid hormone family secreted by mesenchymal stem cells. It is occasionally secreted by cancer cells (for example, breast cancer, certain types of lung cancer including squamous-cell lung carcinoma).

该基因编码的蛋白质是甲状旁腺激素家族的一员。 这种激素通过其受体 PTHR1，在乳腺和牙齿形成过程中调节软骨内骨发育和上皮-间充质相互作用。 它是大多数恶性肿瘤体液性高钙血症病例的原因，该基因的突变与 E2 型短指畸形 (BDE2) 相关。 已发现该基因的可变剪接转录物变体。 还有证据表明，非 AUG (CUG 和 GUG) 起始位点位于起始密码子 AUG 密码子的下游，可替代翻译起始，从而产生这种激素的核形式。 [RefSeq 提供，2013 年 11 月] The protein encoded by this …

2024年11月27日 · In addition, your package will include a detailed data report in both TSV and JSONL formats. The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth.

2012年7月1日 · PTHLH is a protein polyhormone produced by most if not all tissues in the body. It is secreted during both fetal and postnatal life. Although PTHLH is found in the circulation, most of its activity appears to be paracrine.

2024年12月10日 · This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2).

This gene encodes a member of the parathyroid family of Hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of Apoptosis.

Parathyroid hormone-like hormone (PTHLH) is an important factor in renal fibrosis and regulates several processes, including EMT. Herein, we investigated the role of PTHLH-induced EMT in intestinal fibrosis associated with Crohn disease.