2024年12月25日 · PTK2B (Protein Tyrosine Kinase 2 Beta) is a Protein Coding gene. Diseases associated with PTK2B include Hematologic Cancer and Leukemia, Acute Lymphoblastic. Among its related pathways are ERK Signaling and Development Angiotensin activation of ERK.

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene. [5][6] This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway.

2023年11月21日 · Collectively, PTK2B enhances the oligomerization of TBK1 and STING via different mechanisms, subsequently regulating STING-TBK1 activation to ensure efficient antiviral innate immune responses.

该基因编码细胞质蛋白酪氨酸激酶，该激酶参与钙诱导的离子通道调节和图谱激酶信号通路的激活。 编码的蛋白质可能代表神经肽激活受体或增加钙通量的神经递质与调节神经元活动的下游信号之间的重要信号中间体。 编码的蛋白质经历快速酪氨酸磷酸化和激活，以响应细胞内钙浓度的增加、烟碱型乙酰胆碱受体激活、膜去极化或蛋白激酶 C 激活。 该蛋白已被证明可结合 CRK 相关底物、nephrocystin、与 FAK 相关的 GTPase 调节剂和 GRB2 的 SH2 结构域。 编码的蛋白质是蛋 …

Missense mutation in PTK2B gene is associated with hypertension ErbB-2, via PYK2-MAP kinase, upregulates the adhesive ability of androgen receptor human prostate cancer cells. Endothelial Pyk2 activity is required for efficient neutrophil migration and to facilitate junctional disruption during transcellular or paracellular passage of the ...

2023年11月21日，中科院动物所孙钦秒和云南大学陈大华团队在 Nature communications 期刊发表一篇名为“ PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling ”的研究，该研究发现蛋白酪氨酸激酶2B（PTK2B）作为TBK1的互作蛋白，可以磷酸化TBK1，促进TBK1的寡聚化、STING的寡聚化，以及下游信号转导介导的抗病毒先天免疫反应。 TBK1 是先天性免疫反应中的一个关键激酶。 它能使 IRF3/7 磷酸化，诱导其二聚化和核转位， …

2024年4月22日 · PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis. High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma. Zhang C, Zhu X, Li Y, Shao J, Xu H, Chen L, Dan Y, Jin H, He AZhang C, et al. Medicine (Baltimore), 2022 Oct 14. PMID 36253980.

ptk2b （protein tyrosine kinase 2 beta） 该基因编码胞质蛋白酪氨酸激酶，参与钙诱导的离子通道调节和MAP激酶信号通路的激活。

Enables 3-phosphoinositide-dependent protein kinase binding activity; calmodulin-dependent protein kinase activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell communication; and positive regulation of cellular biosynthetic process.

2025年2月19日 · the non-receptor protein tyrosine kinase 2 beta (PTK2B) plays a critical role in murine beige adipocyte differentiation. Data provide evidence that activated PYK2 may function as a component of the microtubule organizing center to regulate spindle assembly during the meiotic process of mouse oocytes.