2024年12月25日 · PTPRB (Protein Tyrosine Phosphatase Receptor Type B) is a Protein Coding gene. Diseases associated with PTPRB include Liver Angiosarcoma and Generalized Epilepsy …

Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the PTPRB gene. [ 5 ] [ 6 ] Function

PTPRB is a prognostic marker in Cervical squamous cell carcinoma and endocervical adenocarcinoma, Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma

The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored predominantly truncating mutations in 10 of 39 angiosarcoma tumors. …

2019年4月30日 · Dysregulation of protein tyrosine phosphatase, receptor type B (PTPRB) correlates with the development of a variety of tumors. Here we show that PTPRB promotes...

2014年3月16日 · We identified recurrent mutations in two genes, PTPRB and PLCG1, which are intimately linked to angiogenesis. The endothelial phosphatase PTPRB, a negative regulator …

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。 已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。 该 PTP 含有一个胞外结构域、一 …

2014年9月29日 · Protein tyrosine phosphatases (PTPs) are enzymes that remove phosphate from tyrosine residues in proteins. Recent whole-exome sequencing of human cancer genomes …

Vascular endothelial protein tyrosine phosphatase (VE-PTP, PTPRB) is a receptor type phosphatase that is crucial for the regulation of endothelial junctions and blood vessel …

2017年10月15日 · PTPRB is a transmembrane protein tyrosine phosphatase known to regulate blood vessel remodelling and angiogenesis. Here, we demonstrate that PTPRB negatively …