2024年12月25日 · PTPRG (Protein Tyrosine Phosphatase Receptor Type G) is a Protein Coding gene. Diseases associated with PTPRG include Chromosome 3Pter-P25 Deletion Syndrome and Breast Disease. Among its related pathways is PAK Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein tyrosine phosphatase activity.

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene. [4] [5]The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and …

PTPRG is a JAK2 phosphatase that negatively regulates leukocyte integrin beta2 activation. Mutations in PDGFRB cause infantile myofibromatosis while a mutation in PTPRG may act as an aggravating factor. Germline polymorphisms in PTPRG gene is associated with lung adenocarcinoma.

Protein tyrosine phosphatase receptor gamma (PTPRG) is known to interact with and regulate several tyrosine kinases, exerting a tumor suppressor role in several type of cancers. Its wide expression in human tissues compared to the other component of ...

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。 已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。 该 PTP 具有一个胞外区、一个跨膜区和两个串联的胞质内催化结构域，因此代表受体型 PTP。 该 PTP 的胞外区包含一个碳酸酐酶样 (CAH) 结构域，该结构域也存在于 PTPRBETA/ZETA 的胞外区。 该基因位于肾癌和肺癌中常缺失的染色体区域，被认为是候选抑癌基因。 [RefSeq 提供，2008 年 7 月] The protein encoded …

2021年4月23日 · Protein tyrosine phosphatase receptor gamma (PTPRG) is a member of the receptor-like family protein tyrosine phosphatases and acts as a tumor suppressor gene in...

Title: A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease. Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors.

PTPRG is a widely expressed protein tyrosine phosphatase present in various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques. We aim at characterizing the plasmatic PTPRG (sPTPRG) form and to identify its source.

与人类的PTPRG（蛋白质酪氨酸磷酸酶受体类型G）正链同源。 [由基因组资源联盟，2022年4月提供]

预测能够实现相同的蛋白质结合活性和蛋白质酪氨酸磷酸酶活性。参与大脑发育和对神经元突起发育的负调控。位于细胞外空间。与人类的ptprg（蛋白质酪氨酸磷酸酶受体类型g）具有同源性。[由基因组资源联盟，2022年4月提供]