The PTRS-41 (Russian: Противотанковое самозарядное ружьё образца 1941 года системы Симонова, romanized: Protivotankovoye samozaryadnoye ruzhyo obraztsa 1941 goda …

Here we find that pTRS1 enhances internal ribosome entry site (IRES) activity using a novel circular RNA reporter that lacks an mRNA cap and poly (A) tail. Additionally, pTRS1 …

2016年3月28日 · We have identified inhibition of the antiviral kinase PKR by the viral proteins TRS1 and IRS1 and shown that this is a critical step in HCMV replication. Our results suggest …

Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus replication. …

2016年3月28日 · In this study, we found that expression of either pTRS1 or pIRS1 is necessary to prevent PKR activation during HCMV infection and that antagonism of PKR is critical for …

The virus-coded proteins pIRS1 and pTRS1 were found associated with purified human cytomegalovirus virions. The proteins were not degraded when intact virions were treated with …

pTRS1 expressed by cell-free translation or infection binds dsRNA. Since previous work determined that TRS1 can complement E3L function in restoring the host cell range of …

2004年2月24日 · More recently, pTRS1 and pIRS1 have been shown to block the double-stranded RNA-dependent protein kinase R response pathway, an antiviral pathway that shuts …

2017年2月14日 · Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits …

RS1 and pIRS1 is critical for viral protein expression and efficient HCMV replication. IMPORTANCE To. successfully replicate, viruses must counteract host defenses that limit viral …