PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions, PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in …

PU.1表达在粒细胞和巨噬细胞分化过程中增加，而在T淋巴细胞和B淋巴细胞分化过程中降低。 本研究回顾并讨论了转录因子PU.1对免疫细胞分化的影响。 转录因子PU.1是ETS家族的重要成 …

2010年6月3日 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by …

PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews …

Ets 转录因子 PU.1 对于诱导胎儿肝脏和成人骨髓中的单核细胞、巨噬细胞和 B 细胞的分化至关重要。 PU.1 通过与其他转录因子（例如 C/EBPα 和 AP-1 家族成员 c-Jun）的物理相互作用来 …

2020年1月21日 · Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the …

2020年10月21日 · PU.1 regulates gene expression in early T cells positively and negatively via two distinct mechanisms: It not only opens chromatin and nucleates with transcriptional co …

We found that conditional ablation of the Ets-family transcription factor PU.1 in DC-restricted progenitors led to increased pDC production at the expense of cDCs. PU.1 controlled many of …

1999年4月1日 · PU.1 controls important genes required for the normal maturation and differentiation of B cells (e.g. immunoglobulins, MB1) and macrophages (M-CSF receptor), …

PU.1是ETS转录因子家族(E26 transformation-specific family)的成员,在机体多种组织发育中发挥重要作用.近年来的研究发现,PU.1不仅在造血谱系的确定和分化中起作用,而且还在机体免疫,脂 …