Pulmonary vascular remodeling patterns and expression of …
Background: Heritable pulmonary veno-occlusive disease (PVOD) is linked to mutations in the eukaryotic initiation factor 2 alpha kinase 4 (EIF2AK4) gene, leading to a loss of general …
GCN2 Regulates ATF3-p38 MAPK Signaling Transduction in ... - PubMed
GCN2 dysfunction led to an enhanced transcription of collagen I gene (col1a1 and col1a2) through decreasing ATF3-dependent p38 phosphorylation inhibition in PVOD, which promotes …
JCI Insight.：GCN2 激酶激活介导肺血管重塑和肺动脉高压 …
2024年10月5日 · EIF2AK4基因（编码GCN2）的隐性突变及其导致的GCN2蛋白表达减少与遗传性肺静脉阻塞病（PVOD）相关，这是一种罕见的严重肺动脉高压（PAH）亚型，特征为隔膜静 …
Pulmonary vascular remodeling patterns and expression of general ...
2018年5月1日 · Heritable pulmonary veno-occlusive disease (PVOD) is linked to mutations in the eukaryotic initiation factor 2 alpha kinase 4 (EIF2AK4) gene, leading to a loss of general …
GCN2 kinase activation mediates pulmonary vascular remodeling …
Recessive mutations in the EIF2AK4 gene (encoding GCN2) and resultant reduction of GCN2 protein expression are linked to heritable pulmonary veno-occlusive disease (PVOD), a rare …
GCN2 Regulates ATF3-p38 MAPK Signaling Transduction in Pulmonary Veno ...
2021年5月14日 · GCN2 dysfunction led to an enhanced transcription of collagen I gene (col1a1 and col1a2) through decreasing ATF3-dependent p38 phosphorylation inhibition in PVOD, …
GCN2 dysfunction led to an enhanced transcription of collagen I gene (col1a1 and col1a2) through decreasing ATF3-dependent p38 phosphorylation inhibition in PVOD, which promotes …
Pulmonary Vascular Remodeling Patterns and Expression of GCN2 …
2017年10月1日 · Background Heritable pulmonary veno-occlusive disease (PVOD) is linked to mutations in the EIF2AK4 gene, leading to a loss of GCN2. The role of GCN2-expression in …
Novel insights into the GCN2 pathway and its targeting.
2024年6月16日 · This consistent pattern of loss or reduction in GCN2 in PVOD, PAH, pulmonary fibrosis, and pulmonary fibrosis-associated pulmonary hypertension strongly suggests a …
Patient-specific and gene-corrected induced pluripotent stem cell ...
2022年12月13日 · In this article, Zhou and colleagues show that PVOD-iPSC-ECs exhibited a decrease in GCN2 protein and mRNA expression, when compared to control and GC-ECs. …