Distribution of proline‐rich (PxxP) motifs in distinct proteomes ...
2004年2月1日 · We have conducted a survey of proline‐rich (PxxP) motifs in the proteomes of human, mouse, yeast, Mycobacteriumtuberculosis and Plasmodiumfalciparum. Our analyses …
The PXXP domain is critical for the protective effect of BAG3 in ...
The PXXP domain of BAG3 was determined to be critical for BAG3-mediated attenuation of H9C2 cell apoptosis induced by H/R through the binding of PXXP with HSC70. The abolished …
Recognition of tandem PxxP motifs as a unique Src homology 3 ... - PNAS
2010年11月22日 · Our complex structure reveals a unique type of SH3 interaction based on recognition of tandem PxxP motifs in the ligand. Strikingly, the specificity pocket of IRTKS SH3 …
Effect of central PxxP motif in amphipathic alpha-helical peptides …
2023年8月9日 · Previous studies have shown that a PxxP motif near the middle of cathelicidin-derived antimicrobial peptides contributes to potent and selective antibacterial activity. In this …
Diverse recognition of non-PxxP peptide ligands by the SH3 …
2002年8月8日 · A PxxP motif and a non-PxxP motif in the same polypeptide chain can generate a protein ligand with high affinity and specificity via the multivalent binding mechanism, as seen …
Modulation of peroxisomal import by the PEX13 SH3 domain and …
2024年4月18日 · Surprisingly, the potential PxxP binding surface of the SH3 domain does not recognize PEX14 PxxP motifs, distinct from its yeast ortholog. Our data show that the dynamic …
UBQLN2 Mediates Autophagy-Independent Protein Aggregate …
2016年8月11日 · Here, we describe a new pathway for maintaining protein homeostasis mediated by the proteasome shuttle factor UBQLN2. The 26S proteasome degrades polyubiquitylated …
SH3 蛋白结构域 | 脯氨酸富集基序 | Cell Signaling Technology
脂肪族残基通常在每个脯氨酸的前面，每个脂肪族脯氨酸对则与 SH3 结构域上的疏水口袋相结合。 原则上，配体能以任意一种方向结合。 其它非脯氨酸残基（经常是 Arg）结合 SH3 结构 …
HIV-1 Nef中富含脯氨酸（PxxP）的基序与Src激酶子集的SH3结构 …
人免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒Nef蛋白包含一个保守的基序，具有最小的Src同源区域3（SH3）介导的蛋白-蛋白相互作用的共有（PxxP）位点。 Nef PxxP基序显示与Hck和Lyn …
Distribution of proline-rich (PxxP) motifs in distinct proteomes ...
2004年3月1日 · We have conducted a survey of proline-rich (PxxP) motifs in the proteomes of human, mouse, yeast, Mycobacterium tuberculosis and Plasmodium falciparum. Our analyses …