Distribution of proline‐rich (PxxP) motifs in distinct proteomes ...
2004年2月1日 · We have conducted a survey of proline‐rich (PxxP) motifs in the proteomes of human, mouse, yeast, Mycobacteriumtuberculosis and Plasmodiumfalciparum. Our analyses …
Recognition of tandem PxxP motifs as a unique Src homology 3 ... - PNAS
2010年11月22日 · Our complex structure reveals a unique type of SH3 interaction based on recognition of tandem PxxP motifs in the ligand. Strikingly, the specificity pocket of IRTKS SH3 …
Effect of central PxxP motif in amphipathic alpha-helical peptides …
2023年8月9日 · The central PxxP motif, which consists of a proline (P) followed by any two amino acids (x) and another proline (P), induces a hinge that significantly affects the antimicrobial …
Modulation of peroxisomal import by the PEX13 SH3 domain and …
2024年4月18日 · By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions with a proximal FxxxF …
The Structure and Function of Proline Recognition Domains
2003年4月22日 · In vitro peptide selection studies revealed that the majority of SH3 domains require the conserved consensus motif PxxP for recognition. In individual SH3 domains, …
SH3 domain ligand binding: What’s the consensus and where’s the ...
2012年8月14日 · This bacterial peptide contains a typical PPII-helical PxxP motif to interact with the xP pocket region of IRTKS SH3 as a Class I ligand, but exploits a unique strategy for …
SH3 蛋白结构域 | 脯氨酸富集基序 | Cell Signaling Technology
结合 mSOS 肽（红色）的 SEM-5 的羧基末端 SH3 结构域。 S rc- 同源 3 (SH3) 结构域结合脯氨酸富集肽，这种肽会与最小的共有 Pro-X-X-Pro 形成左侧聚脯氨酸 II 型螺旋。 脂肪族残基通常 …
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a …
2001年1月1日 · Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif with the minimal consensus (PxxP) site for Src homology …
The Central PXXP Motif Is Crucial for PMAP-23 Translocation …
The central hinge induced by a PXXP motif drives conformational flexibility of amphipathic α-helical structures, which may be the driving force for PMAP-23 translocation across the lipid …
The Central PXXP Motif Is Crucial for PMAP-23 Translocation
2021年9月9日 · PMAP-23, a cathelicidin-derived host defense peptide, does not cause severe membrane permeabilization, but exerts strong and broad-spectrum bactericidal activity. We …