PYCR1 Gene - GeneCards | P5CR1 Protein | P5CR1 Antibody
2024年12月25日 · PYCR1 (Pyrroline-5-Carboxylate Reductase 1) is a Protein Coding gene. Diseases associated with PYCR1 include Cutis Laxa, Autosomal Recessive, Type Iib and …
PYCR1 - Wikipedia
Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene. [5] [6] This gene encodes an enzyme that catalyzes the NAD(P)H-dependent …
PYCR1 promotes liver cancer cell growth and metastasis by …
Pyrroline-5-carboxylate reductase 1 (PYCR1) promotes the proliferation and metastasis of liver cancer (LC) cells. The expression of PYCR1 in LC is regulated by DNA methylation. Knocking …
吡咯啉-5-羧酸还原酶 1（PYCR1）基因 | MCE - MCE-生物活性 ...
该基因编码一种酶，该酶催化 NAD (P) H 依赖性吡咯啉-5-羧酸盐转化为脯氨酸。 这种酶也可能在某些细胞类型的 NADP (+) 生成中发挥生理作用。 该蛋白质形成均聚物并定位于线粒体。 可 …
吡咯啉-5-羧酸还原酶-1在恶性肿瘤中的研究进展 - 中华临床实验室 …
吡咯啉-5-羧酸还原酶-1 (Pyrroline-5-Carboxylate Reductase-1, PYCR1)是一种线粒体酶，其基因突变可导致人类皮肤松弛症。 近年研究证明PYCR1能通过影响脯氨酸代谢发挥促进肿瘤生长增 …
PYCR1 pyrroline-5-carboxylate reductase 1 [ (human)]
A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family. The phenotype caused by PYCR1 mutations corresponds to geroderma …
PYCR1在结肠癌中的表达及对细胞的增殖、侵袭及迁移的影响
PYCR1 (pyrroline-5-carpoxylate reductase-1，吡咯啉-5-羧酸还原酶-1)，是P5C (pyrroline-5-carpoxylate)转化为脯氨酸的依赖NADP的关键酶，位于染色体17q25.3，其变异会导致一种使 …
脯氨酸生物合成酶吡咯啉-5-羧酸还原酶 (PYCR) 的结构、生物化学 …
PYCR 催化 Δ 1 - 吡咯啉-5-羧酸盐依赖 NAD (P)H 还原为脯氨酸，并形成脯氨酸代谢循环的还原半部分。 我们综述了PYCR的三维结构、生物化学、抑制作用和癌症生物学方面的研究。 为了 …
吡咯啉--5--羧酸还原酶1调控非小细胞肺癌细胞增殖及转移的机制 …
吡咯啉-5-羧酸还原酶1（Pyrroline-5-carboxylatereductase1,PYCR1）参与脯氨酸代谢，催化吡咯啉-5-羧酸还原为脯氨酸，脯氨酸的代谢在肿瘤的发生中非常重要。 前人的研究发现，PYCR1 …
Proline synthesis through PYCR1 is required to support cancer cell ...
In this study, we show that mitochondrial proline synthesis, specifically through PYCR1 activity, is essential to support hypoxic metabolism and viability. Loss of PYCR1 in vivo results in an …