Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts …

2024年4月1日 · PYK2 functions as a signaling hub in various cascades, and its involvement in positive and negative feedback loops enhances signaling robustness, modulates signaling …

聚合黏附激酶 (Focal adhesion kinase, FAK)是一种非受体酪氨酸激酶，也是一种连接蛋白，主要调节黏附信号传导和细胞迁移，但FAK也可以促进细胞在应激反应中的生存。 FAK在癌症中普遍 …

2018年11月14日 · Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell …

富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）是黏着斑激酶（focal adhesion kinase，FAK）家族的一员，Pyk2可使多种含SH2结构域的底物蛋白发生磷酸化，从而参与包 …

摘要： 富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）广泛存在于细胞和组织中，参与多种生理及病理过程，发挥其生物学效应。 Pyk2依赖N-末端、C-末端和中心激酶结 …

2022年8月9日 · Here, we investigated the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx. We show that the linker …

Pyk2 is a Ca 2+ -activated non-receptor tyrosine kinase enriched in forebrain neurons and involved in synaptic regulation. Human genetic studies associated PTK2B, the gene coding …

The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer's disease (AD) susceptibility variant, with the PTK2B risk allele being associated with increased mRNA levels, …

Proline-rich tyrosine kinase 2 (Pyk2) is a nonreceptorprotein tyrosine kinase related to focal adhesion kinase (FAK). Pyk2 is activated by an array of stimuli, including G protein-coupled …