2009年11月8日 · Recently a family of proteins known as PYR/PYL/RCAR have been identified, the members of which bind ABA and mediate inactivation of ABI1 and ABI2. Here Márquez and colleagues present the ...

Pyr 1 is a cell permeable competitive inhibitor of Lim Kinase (especially LIMK1). The latter is the enzyme that uses ATP to phosphorylate and inactivate the actin-depolymerizing factor cofilin. When cofilin is phosphorylated, it regulates actin dynamics. LIMK1 …

2009年10月22日 · Here, we report structures of pyrabactin resistance 1 (PYR1), a prototypical PYR/PYR1-like (PYL)/regulatory component of ABA receptor (RCAR) protein that functions in early ABA signaling. The crystallographic structure reveals an α/β helix–grip fold and homodimeric assembly, verified in vivo by coimmunoprecipitation.

2013年6月27日 · 现在，通过单体和二聚体形式以及与 PP2C 复合的 apo 和全息 PYR1 的广泛分子动力学 (MD) 模拟，研究配体结合对相互作用选择性的动力学贡献，与 ABA 不敏感 1 (HAB1) 同源。 一种新颖的基本集体动力学方法实现了稳健的比较解释。 与最近的实验结果一致，我们的分析表明 ABA 结合的 PYR1 应该有效地与 HAB1 结合。 然而，ABA 结合的和 ABA 提取的 PYR1-HAB1 构建体在其动力学方面表现出显着的相似性，表明 apo-PYR1 也应该能够与 PP2C 进行 …

2013年6月27日 · Protein pyrabactin resistance 1 (PYR1) belongs to a group of PYR1-like (PYL) proteins that regulate plant development and responses to conditions of drought and salinity.

2010年1月8日 · In addition to the identification of PYR/PYL/RCAR proteins as the major proteins co-purified with ABI1 from Arabidopsis plants, the present study reports several further relevant new findings: (i) A new PYR1 antibody was used and showed that the ABI1 protein phosphatase interacts with the PYR1 protein in vivo (ii) ABA stimulates this ...

Recent investigations have revealed two subsets of these receptors that, in the absence of ABA, either form inactive homodimers (PYR1 and PYLs 1-3) or mediate basal inhibition of downstream target type 2C protein phosphatases (PP2Cs; PYLs 4-10) respectively in vitro.

2023年10月23日 · Plants sense abscisic acid (ABA) using chemical-induced dimerization (CID) modules, including the receptor PYR1 and HAB1, a phosphatase inhibited by ligand-activated PYR1. This system is unique...

As abscisic acid (ABA) receptor, the pyrabactin resistance 1-like (PYR/PYL) protein (named PYL for simplicity) plays an important part to unveil the signal transduction of ABA and its regulatory mechanisms. Glycyrrhiza uralensis, a drought-tolerant medicinal plant, is a …

2009年12月3日 · These proteins inhibit in an ABA-dependent manner the activity of a family of key negative regulators of the ABA signalling pathway: the group-A protein phosphatases type 2C (PP2Cs). Here we present the crystal structure of Arabidopsis thaliana PYR1, which consists of a dimer in which one of the subunits is bound to ABA.