Interplay between cofactors and transcription factors in …
2021年1月20日 · Within the complex, the BAF57 subunit is critical for chromatin remodeling and transcription with EKLF. 36,37 An Ikaros–SWI/SNF complex called the PYR complex broadly …
Regulation of human fetal hemoglobin: new players, new …
2006年1月15日 · The proposed role of the PYR complex in human hemoglobin switching. The circles indicate unspecified chromatin remodeling complexes and transcription factors. The …
An overview of structure, function, and regulation of pyruvate …
Structures of PYR complexes have been determined for TbPyK and mammalian M1 and M2 isozymes (Table S1). In these complexes PYR is involved in coordination with the Mg 2+ and …
An Ikaros-Containing Chromatin-Remodeling Complex in Adult-Type ...
Our results suggest that Ikaros targets two types of chromatin-remodeling factors—activators (SWI/SNF) and repressors (NuRD)—in a single complex (PYR complex) to the β-globin locus …
The abscisic acid receptor PYR1 in complex with abscisic acid
2009年11月8日 · Here we describe the crystal structure of the PYR1 protein in complex with ABA at 2.0 Å resolution and elucidate the interactions that stabilize the hormone–receptor complex.
An orthogonalized PYR1-based CID module with reprogrammable …
2023年10月23日 · Plants sense abscisic acid (ABA) using chemical-induced dimerization (CID) modules, including the receptor PYR1 and HAB1, a phosphatase inhibited by ligand-activated …
An ikaros-containing chromatin-remodeling complex in adult …
Competition gel shift experiments using partially purified PYR complex and recombinant Ikaros protein indicate that Ikaros functions as a DNA-binding subunit of the PYR complex. Our …
Molecular Mechanisms in the Activation of Abscisic Acid Receptor …
2013年6月27日 · In this work, we use molecular dynamics simulations complemented by a sophisticated statistical-mechanical analysis to investigate structural and dynamical properties …
Multiple hematopoietic defects and delayed globin switching in …
2002年1月22日 · We have previously reported the structure of a chromatin remodeling complex (PYR complex) with Ikaros as its DNA binding subunit that is specifically present in adult …
PyrR核苷酸复合物的结构，即解热芽孢杆菌的pyr衰减蛋白，表明 …
PyrR是一种蛋白质，可调节许多细菌中嘧啶核苷酸生物合成基因和操纵子的表达（pyr基因）。 当尿苷核苷酸的细胞内水平升高时，PyrR通过与pyr mRNA上的特定序列结合并引起转录减弱而 …