一般人對於輔酶q10的耐受性良好，最常見的副作用是腸胃道症狀（包括噁心、嘔吐、食慾不振和腹痛），其他症狀也包含皮疹和頭痛。 雖然目前還沒有確切的理想劑量，但典型的每日劑量為100-200毫克。另外，不同的配方具有不同的輔酶q10和其他成分含量。

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