2024年12月25日 · QDPR (Quinoid Dihydropteridine Reductase) is a Protein Coding gene. Diseases associated with QDPR include Hyperphenylalaninemia, Bh4-Deficient, C and Hyperphenylalaninemia, Bh4-Deficient, A. Among its related pathways are Tyrosine catabolism and L-phenylalanine degradation I (aerobic).

2024年5月7日 · We demonstrate that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, causes metabolite dihydrobiopterin (BH2) accumulation and decreases the ratio of tetrahydrobiopterin (BH4) to BH2 in pancreatic ductal adenocarcinomas (PDACs).

QDPR (quinoid dihydropteridine reductase) is a human gene that produces the enzyme quinoid dihydropteridine reductase. This enzyme is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4. Tetrahydrobiopterin works with an enzyme called phenylalanine hydroxylase to process a substance called phenylalanine.

该研究发现，在PDAC中，调节生物蝶呤代谢的关键酶醌二氢蝶呤还原酶（QDPR）的缺乏会导致代谢物BH2的积累，并降低BH4/BH2的比值。 中山大学肿瘤防治中心、华南 恶性肿瘤防治全国重点实验室林东昕、郑健、王力勤研究…

该基因编码二氢蝶啶还原酶，该酶催化 NADH 介导的醌类二氢生物蝶呤的还原。 这种酶是依赖蝶呤的芳香族氨基酸羟基化系统的重要组成部分。 该基因中导致 QDPR 缺陷的突变包括异常剪接、氨基酸替换、插入或过早终止。 由于生物蝶呤 (苯丙氨酸羟化酶的辅助因子) 生成不足，二氢蝶啶还原酶缺乏症表现为非典型苯丙酮尿症。 [RefSeq 提供，2008 年 7 月] This gene encodes the Enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of …

Quinoid dihydropteridine reductase is one of two enzymes that help recycle tetrahydrobiopterin in the body. More than 30 mutations in the gene have been found to cause tetrahydrobiopterin deficiency. When this condition results from gene mutations, it is known as dihydropteridine reductase (DHPR) deficiency.

2024年4月22日 · 2024 年 4 月 19 日，来自中山大学的郑健、王力勤和林东昕院士团队，共同在 Cell Metabolism上在线发表题为 「QDPR deficiency drives immune suppression in pancreatic cancer」的研究论文，该研究发现 QDPR（醌型二氢蝶啶还原酶）的缺失会导致 PDAC 对 ICB 治疗产生抵抗性，其主要通过影响生物蝶呤代谢途径，特别是改变四氢生物蝶呤（BH4）和二氢生物蝶呤（BH2）的比率，导致活性氧（ROS）的增加和 H3K27me3 的降低，进而激活 Cxcl1 的 …

2024年9月19日 · Mutation of dihydropteridine reductase (QDPR) inhibited the regulation of TOR serine-threonine kinases (mTOR), suggesting that QDPR is a positive regulator of autophagy via suppressing mTOR signaling. Title: A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling.

2024年4月21日 · 2024年4月19日，中山大学郑健、王力勤及林东昕共同通讯在 Cell Metabolism 在线发表题为“ QDPR deficiency drives immune suppression in pancreatic cancer ”的研究论文， 该研究发现，在胰腺导管腺癌 (PDACs)中，调节生物蝶呤代谢的关键酶—醌类二氢蝶呤还原酶 (QDPR)的缺乏会导致代谢物二氢生物蝶呤 (BH2)的积累，并降低四氢生物蝶呤 (BH4)与BH2的比值。 BH4/BH2比值降低导致活性氧 (ROS)生成增加，H3K27me3在CXCL1启动子处的分布减少 …

We demonstrate that the deficiency of quinoid dihydropteridine reductase (QDPR), a critical enzyme regulating biopterin metabolism, causes metabolite dihydrobiopterin (BH2) accumulation and de-creases the ratio of tetrahydrobiopterin (BH4) to BH2 in pancreatic ductal adenocarcinomas (PDACs).