2022年9月2日 · p300/cbp是肿瘤疾病的重要靶标之一，研究人员长期致力于设计和发现靶向 p300/cbp的优质小分子抑制剂。 根据作用位点的不同，当下的抑制剂化合物的研究主要是从BRD结构域、HAT结构域这两个功能域进行抑制的方法来干扰p300/CBP的功能。

2024年1月18日 · Ferrie et al. demonstrate through live-cell single-molecule imaging that the coactivator p300, a central player in eukaryotic gene regulation, carries out its function of integrating multiple transcription factor (TF) inputs at the level of chromatin binding. Their results support a TF- rather than histone-mediated model of coactivator recruitment.

The P300 (P3) wave is an event-related potential (ERP) component elicited in the process of decision making. It is considered to be an endogenous potential, as its occurrence links not to the physical attributes of a stimulus, but to a person's reaction to it. More specifically, the P300 is thought to reflect processes involved in stimulus ...

2021年5月20日 · Our work reveals that p300/CBP-catalyzed acetylation is a key driver of rapid enhancer activation, and unmasks a critical role of lysine deacetylases (KDACs) in kinetic enhancer deactivation. Notably, p300/CBP inhibition abrogates enhancer activation without altering the binding of TFs and p300.

2021年3月9日 · TF/p300的共凝聚使p300在细胞内局部聚集，促进其反式激活反应，实现对p300催化活性的空间特异的激活，进而协助包括Brd4在内的下游共激活因子的招募。 在目标基因调控层面，TF/p300的共凝聚可以影响目标基因转录的起始速度、转录爆发的持续时间等定量参数 ...

2015年4月16日 · We show that the coactivator p300 has both crotonyltransferase and acetyltransferase activities, and that p300-catalyzed histone crotonylation directly stimulates transcription to a greater degree than histone acetylation.

2018年6月28日 · Time-resolved acetylome analyses identified a subset of CBP/p300-regulated sites with very rapid (<30 min) acetylation turnover, revealing a dynamic balance between acetylation and deacetylation.

摘要: CBP and p300 are two closely related Histone Acetyltransferases (HATs) that interact with numerous transcription factors and act to increase the expression of their target genes. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important in binding of CBP/p300 to chromatin, which offers an opportunity to ...

2024年3月1日 · We describe recent efforts to expand our understanding of P300 beyond its sensitivity to schizophrenia itself to its potential role as a biomarker of risk for psychosis or a heritable endophenotype that bridges genetic risk and psychosis phenomenology.

This study was conducted to evaluate cognitive abnormalities in obstructive sleep apnea (OSA) using cognitive evoked potentials (P300), and to clarify if such cognitive dysfunction is related to the OSA itself or to the hypersomnolence in OSA. Subjects were administered a …