2008年3月19日 · Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition …

R-343: 一种IgE抑制剂、Syk抑制剂药物，由Rigel Pharmaceuticals, Inc. (Rigel Pharmaceuticals, Inc.)公司最早进行研发，目前全球最高研发状态为无进展，作用机制: IgE抑制剂 (免疫球蛋 …

2017年11月10日 · A novel homozygous missense R343H mutation in the exon 9 of VDR residing in the retinoid X receptor (RXR)-binding domain was identified. The expression level and C …

R343 is a syk kinase inhibitor. Syk kinase is a protein tyrosine kinase that plays a pivotal role in high affinity IgE receptor signaling in mast cells.

2011年5月6日 · Rigel's R343 is designed to bind to the syk in mast cells to interrupt the signal from the IgE receptors. R343's ability to inhibit syk potentially prevents or stops the immune …

EXPERT OPINION The use of TKIs, especially inhibitors of Btk, Syk, and Lyn, is a promising new strategy for targeted treatment of B-cell lymphoid malignancies, autoimmune disorders and …

FDA全球物质注册数据库（FDA Global Substance Registration System）

R343是一种免疫球蛋白E（IgE）以及脾酪氨酸激酶（Syk）抑制剂，可用于过敏性哮喘和非小细胞肺癌的相关研究。 立即从AbMole中国订购高品质Syk抑制剂R343！

2006年5月17日 · R343 is designed to block the major pathways that are triggered in allergic asthma. It appears to be particularly appropriate for intrapulmonary delivery due to its limited …

R343检测报告包含了一部分产品质量测试得到的实际结果。 查看R343具体的物理和化学性质以及分析数据。