R848-activated DCs enhanced CD8+ T cell proliferation and increased IFN-γ+CD8+ T cells with the assistance of NK cells. In contrast, depletion of NK cell decreased IFN-γ+CD8+ T cell …

We showed that R848 rather than TLR3 and TLR9 agonists primarily activated CD56 bright CD16-NK cells by increasing their proliferation, cytokine production and cytotoxic activity. …

We showed that R848 rather than TLR3 and TLR9 agonists primarily activated CD56 bright CD16 − NK cells by increasing their proliferation, cytokine production and cytotoxic activity.

我们的结果表明，r848在体内比 tlr4 激动剂（脂多糖）和 tlr9 激动剂（c 类 cpg）更大程度地诱导淋巴结（ln）中的cd8 + t 细胞积累和 ifn-γ + cd8 + t 细胞。 r848 激活的 dc 增强 cd8 + t 细胞 …

摘要 目的研究R848对人自然杀伤细胞 (NK)杀伤功能的作用及其机制。 方法分离健康志愿者外周血单个核细胞 (PBMC)、纯化NK细胞,加或不加R848进行培养。 分别在0、2、6、24、48h收集 …

目的研究R848对人自然杀伤细胞 (NK)杀伤功能的作用及其机制.方法分离健康志愿者外周血单个核细胞 (PBMC),纯化NK细胞,加或不加R848进行培养.分别在0,2,6,24,48h收集培养细胞,流式细 …

2024年7月8日 · Results revealed that Poly I:C and Imiquimod enhanced the activation of both immunoregulatory and cytotoxic NK cells, increasing IFN-γ, CD107a, NKG2D, and NKp44 …

本课题通过体内和体外实验，逐步验证这一假设并阐明r848诱导nk细胞向淋巴结聚集，促进dc-nk相互作用，增强th1型免疫反应的具体机制。 此研究将为新型疫苗佐剂的筛选和研究提供新 …

2022年1月26日 · The first relevant result of the study is that R848, rather than Poly I:C and ODN2395, gives the strongest signal upregulating NK-cell function. Indeed, we found that the …

Systemic administration of R848 upregulated TLR7 expression in dendritic cells (DCs) and enhanced the activation of DCs and natural killer (NK) cells. Moreover, this treatment also …