2024年12月25日 · RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB7B include Charcot-Marie-Tooth Disease Type 2B and Hemolytic-Uremic Syndrome. Among its related pathways are Rab regulation of trafficking and Vesicle-mediated transport.

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene. [5] Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells. [6] .

2025年2月8日 · study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B

RAB7B is a prognostic marker in Ovary serous cystadenocarcinoma, Uterine corpus endometrial carcinoma

2025年2月8日 · Rab7b is required for sortilin transport from endosomes to the TGN. Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production. Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network.

FUNCTION: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation.

rab7b，成员 ras 致癌基因家族： 预测启用 gtp 结合活动和 gtpase 活动。 参与晚期内体到高尔基体的运输；巨核细胞分化的正调控；和基因表达的调控。 位于细胞质囊泡中；溶酶体；和跨高尔基网络。

2004年6月4日 · Here we report the cloning and characterization of a novel Rab7-like GTPase, which shares highest homology with Rab7 and thus is designated as Rab7b. Northern blot analysis shows that Rab7b mRNA is expressed in human heart, placenta, lung, skeletal muscle, and peripheral blood leukocyte.

Gene ID: 226421, updated on 8-Feb-2025. Summary. Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of toll-like receptor 4 signaling pathway and negative regulation of toll-like receptor 9 signaling pathway. Acts upstream of or within cellular response to type II interferon.

Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family. The transcriptional landscape of the mammalian genome. Structural basis for integration of GluD receptors within synaptic organizer complexes. Predicted to enable GTP binding activity and GTPase activity.