2011年7月1日 · In the present study, we demonstrated that LPS induced Rac1 and Rac2 activation in lungs, and specific inhibition of both Rac1 and Rac2 activities by NSC23766 effectively attenuated LPS-induced pulmonary inflammation through inhibition of inflammatory cells migration and reduction of vascular permeability, suggesting that Rac is a physiological ...

2001年8月10日 · In the present study, we provide functional and biochemical evidence that Rac1 induction of NFκB is partially responsible for LPS-induced TNFα production. Activation of this pathway by LPS is dependent on Rac1-mediated ROS formation and the subsequent activation of the IKK complex, but appears to be independent of the CD14 receptor.

LPS activated both Rac1 and Rac2, but not CDC42 or RhoA activities in lungs, and specific inhibition of Rac activities by NSC23766 effectively alleviated LPS-induced injury. General significance: Rac could be a potential target for therapeutic intervention of …

2002年6月21日 · Our findings establish for the first time that LPS-mediated PTK/phosphatidylinositol 3-kinase/Rac/p38 pathways play a more important role than pathways of PTK/PKC/MEK/ERK and of PTK/phosphatidylinositol 3-kinase/Rac/JNK in the …

Our findings establish for the first time that LPS-mediated PTK/phosphatidylinositol 3-kinase/Rac/p38 pathways play a more important role than pathways of PTK/PKC/MEK/ERK and of PTK/phosphatidylinositol 3-kinase/Rac/JNK in the regulation of pro-IL-1/IL-1.

In summary, our data demonstrate that LPS disrupts endothelial barrier properties by decreasing intracellular cAMP. This mechanism may involve inactivation of Rac 1 rather than activation of Rho A. Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro

2008年6月10日 · Recent studies have shown that Toll-like receptors (TLRs) play an important role in promoting the clearance of bacteria by up-regulating the phagocytic activity of...

2004年9月17日 · Subcellular fractionation reveals that lipopolysaccharide induces translocation of Cdc42 to lipid rafts, where it and p38 are both found to be activated. By contrast, lipopolysaccharide causes translocation of Rac from the polymorphonuclear leukocyte (PMN) rafts and does not induce its activation.

2021年6月10日 · Mechanistically, LPS stimulates TLR4 to induce Piezo1-mediated calcium influx and consequently activates CaMKII-Mst1/2-Rac axis for pathogen ingestion and killing. Inhibition of CaMKII or...

2015年9月29日 · In the present study, we sought to elucidate the role of the Rho/Rho kinase (ROCK) pathway in the release of tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) following injection of LPS...