Rac/Cdc42 and p65PAK Regulate the Microtubule ... - ScienceDirect
2001年1月19日 · Rac and Cdc42 regulate actin polymerization and form membrane protrusions at the leading edge of migrating cells and neuronal growth cones. The results described here …
Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle …
1996年11月1日 · Rac and Cdc42 containing a Y40C effector site substitution no longer intact with the Ser/Thr kinase p65 PAK and are unable to activate the JNK MAP kinase pathway. …
NF-κB p65 Overexpression Promotes Bladder Cancer Cell …
RESULTS: p65 protein was remarkably upregulated in the BBN-induced high invasive BCs and in human BC cell lines. We also observed that p65 overexpression promoted BC cell migration …
A Conserved Binding Motif Defines Numerous Candidate Target …
1995年12月8日 · In this report, we have localized the Cdc42 binding site of a murine p65 PAK isoform to a minimal conserved region of 16 amino acids. Using this small protein motif, we …
FGD3 binds with HSF4 to suppress p65 expression and inhibit
2022年1月3日 · Since p65 was one of the most upregulated genes after FGD3 silencing in the RNA-seq dataset, we hypothesized that FGD3 represses p65 expression to inactivate NF-κB …
A domain containing the Cdc42/Rac interactive binding (CRIB) …
1997年3月10日 · Coexpression of a mutant of p65 PAK, PAK/RD, lacking the kinase domain but containing the Cdc42/Rac interactive binding (CRIB) region, suppressed the TRE activation …
A novel serine kinase activated by rac1/CDC42Hs-dependent ...
1995年5月1日 · Recombinant hPAK65 exhibits identical specificity to the endogenous p65; both can bind rac1 and CDC42Hs in a GTP-dependent manner. The GTP-bound forms of rac1 and …
Rac and Cdc42 induce actin polymerization and G1 cell cycle
1996年11月1日 · Rac and Cdc42 containing a Y40C effector site substitution no longer intact with the Ser/Thr kinase p65PAK and are unable to activate the JNK MAP kinase pathway. …
(PDF) Rac and Cdc42 induce actin polymerization and G1 cell cycle ...
1996年12月1日 · Rac and Cdc42 containing a Y40C effector site substitution no longer intact with the Ser/Thr kinase p65PAK and are unable to activate the JNK MAP kinase pathway. …
Toll-like receptor 2–mediated NF-κB activation requires a Rac1 ...
Here we provide evidence that Rac1 is a key regulator of a second, parallel, pathway required for the transcriptional activity of the NF-κB p65 subunit in response to Gram-positive stimuli.