2023年7月17日 · A RAD51C mutation increases your risk for ovarian cancer. A RAD51C mutation may also increase your risk for breast cancer, but more research is needed for us to better understand this risk. While a RAD51C mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood ...

The RAD51C gene is one of genes four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression.

2024年12月25日 · RAD51C (RAD51 Paralog C) is a Protein Coding gene. Diseases associated with RAD51C include Breast-Ovarian Cancer, Familial 3 and Fanconi Anemia, Complementation Group O. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.

基于DNA损伤修复原理在PARP上取得的成功以及PARP抑制剂耐药的出现，一些相关靶点RAD51、Wee1、ATM、ATR、PRMT5等也引起了研发人员的极大热情，成为近年来的热门研发方向。 RAD51参与HR过程并诱发癌症耐药性. RAD51基因是编码一条339个氨基酸且相对分子质量为4.3×104的多肽，具有XRCC2、XRCC3、RAD51B (RAD51L1)、RAD51C (RAD51L2)、RAD51D ( RAD551L3) 5个同系物，它们与RAD51共同参与HR过程。 由于修复时需要利用未受损的同 …

2024年9月22日 · Women with a RAD51C mutation have about a 10-15 percent lifetime risk for ovarian, fallopian tube or primary peritoneal cancer (these three cancers and their risks are related and are often referred to together as ovarian cancer).

2024年9月18日 · Pathogenic variants in RAD51C confer an elevated risk of breast and ovarian cancer, while individuals homozygous for specific RAD51C alleles may develop Fanconi anemia. Using saturation genome editing (SGE), we functionally assess 9,188 unique variants, including >99.5% of all possible coding sequence single-nucleotide alterations.

2023年7月24日 · Here we report the RAD51C-XRCC3 (CX3) X-ray co-crystal structure with bound ATP analog and define separable RAD51C replication stability roles informed by its three-dimensional structure,...

RAD51C and RAD51D are moderate ovarian cancer susceptibility genes. RAD51C mutation is associated with breast and ovarian cancer. The effect of common single nucleotide polymorphisms (SNPs) in non-coding regions of RAD51C in modulating the risk of breast cancer was investigated. Mutations in RAD51C are associated with drug resistance in breast ...

Abnormal expression of Rad51C, which is a key factor in the HR pathway, may result in DNA repair disorder, genomic instability, and eventually lead to tumor formation. In recent studies, researchers considered Rad51C as a potential target for cancer treatment. We reviewed the research progress on Rad51C in DNA damage repair and radiotherapy.

What is my cancer risk if I have a RAD51C mutation? A RAD51C mutation increases your risk for ovarian cancer. A RAD51C mutation may also increase your risk for breast cancer, but more research is needed for us to better understand this risk. While a RAD51C mutation means you have a somewhat higher risk of