2023年7月17日 · A RAD51D mutation increases your risk for ovarian cancer. A RAD51D mutation may also increase your risk for breast cancer, but more research is needed for us to better understand this risk. While a RAD51D mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood ...

2024年12月25日 · RAD51D (RAD51 Paralog D) is a Protein Coding gene. Diseases associated with RAD51D include Breast-Ovarian Cancer, Familial 4 and Hereditary Breast Ovarian Cancer Syndrome.Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.Gene Ontology (GO) annotations related to this gene include ...

rad51d 基因突变会增加罹患卵巢癌的⻛险。 rad51d 突变也可能会增加罹患乳腺癌的⻛ 险，但我们还需要进⾏更多研究才能更好地了解这种⻛险。 虽然 rad51d 基因突变意味着罹患癌症的⻛险⽐普通⼈要⾼⼀些，但这并不能完全解释为 什么您的⾎亲会罹患癌症。

RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination. DNA Repair 76:99–107 [PMC free article] [Google Scholar] 6. Ball LG, Zhang K, Cobb JA, Boone C, Xiao W. 2009. The yeast Shu complex couples error-free post-replication repair to homologous recombination.

2023年6月21日 · a, Domain architectures of RAD51, RAD51B, RAD51C, RAD51D and XRCC2 protein subunits.b, Front and back views of the cryo-EM map (2.2 Å) and atomic model of BCDX2 in the presence of ADP.AlFx. c ...

2024年9月22日 · Risk Management for People with Inherited RAD51D Mutations. Experts at the National Comprehensive Cancer Network (NCCN) created guidelines help people with a RAD51D make decisions about managing their cancer risk.. We recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you decide on a plan for managing your risk.

RAD51 旁系同源 D： 该基因编码的蛋白质是 RAD51 蛋白质家族的成员。 RAD51 家族成员与细菌 RecA 和酿酒酵母 RAD51 高度相似，已知它们参与 DNA 的同源重组和修复。该蛋白质与 RAD51 家族的其他几个成员形成复合物，包括 RAD51L1、RAD51L2 和 XRCC2。与该蛋白质形成的蛋白质复合物已被证明可催化单链和双链 DNA ...

2024年9月6日 · Mutations in the RAD51D gene have been linked to increased risk for breast, fallopian tube and ovarian cancer. Researchers are studying whether these mutations increase the risk for other cancers. What can people with a RAD51D mutation do? Expert guidelines include recommendations for people with RAD51D mutations on managing their cancer risk.

2013年12月4日 · Inhibition of RAD51D synthesis in telomerase-negative immortalized human cells by small interfering RNA also resulted in telomere erosion and chromosome fusion. Tarsounas et al. (2004) concluded that RAD51D plays a dual cellular role in both the repair of DNA double-strand breaks and telomere protection against attrition and fusion.

人类Rad51蛋白是同源重组的关键酶,发挥着链转移或链交换活性,启动DNA同源配对的作用.Rad51D蛋白是Rad51蛋白的5种同源物之一,对细胞调节有正反两种作用机制:一方面作为辅助因子参与DNA修复同源重组,维持正常细胞周期;另一方面又是诱发癌症病变,防止癌细胞衰老的因素之一.Rad51D蛋白对细胞的作用机制 ...