Retinoblastoma protein - Wikipedia
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One …
RB1 Gene - GeneCards | RB Protein | RB Antibody
Dec 25, 2024 · RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Small Cell Cancer Of The Lung. Among its …
Pan-cancer molecular analysis of the RB tumor suppressor …
Apr 2, 2020 · The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and therapeutic responses.
RB1 RB transcriptional corepressor 1 [ Homo sapiens (human) ]
Mar 4, 2025 · Title: Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance. Retinoblastoma-associated protein is important for TRIM24-mediated activation of …
RB1 gene - MedlinePlus
Hundreds of mutations in the RB1 gene have been identified in people with retinoblastoma, a rare type of eye cancer that typically affects young children. This cancer develops in the retina, …
Cell cycle and beyond: Exploiting new RB1 controlled mechanisms …
Canonically, RB1 regulates cell cycle progression and represents the down-stream target for CDK4/6 inhibitors that are in clinical use. However, newly discovered features of the RB1 …
RB1 : governor of the cell cycle in health and disease-a ... - PubMed
Jun 19, 2024 · RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the …
The retinoblastoma tumor-suppressor gene, the exception that …
Aug 28, 2006 · Hereditary retinoblastoma is caused by germline transmission of one mutationally inactivated Rb1 allele and loss of the remaining wild-type allele in somatic retinal cells.
Frontiers | The significance of RB1 in multiple myeloma
Nov 26, 2024 · The retinoblastoma gene (RB1), located in 13q14, encodes the retinoblastoma protein (pRB), a tumor suppressor that regulates cell cycle progression. Deletion of RB1, …
Rb1 Gene - Functions, Mutations, and Clinical Implications
Dec 20, 2023 · The Rb1 gene, also known as the retinoblastoma gene, is a tumor suppressor gene that plays a crucial role in regulating cell growth and preventing the development of …