2022年11月1日 · Results: Fourteen of 208 (6%) SCLC expressed wild-type Rb, accompanied by a unique p16-low/cyclinD1-high profile supporting Rb proficiency. Rb-proficient SCLC was …

In this study, we performed analysis of RB1 genomic alterations by broad targeted NGS concurrently with Rb protein IHC in 208 clinical samples of SCLC and further documented Rb …

Aids in the identification of high-grade neuroendocrine carcinomas and small cell carcinomas. For the initial technical component only immunohistochemical (IHC) stain performed, the …

2023年9月22日 · RB1 mutation contributes to YAP transcriptional silencing via E2F7, which recruits the RCOR co-repressor complex to YAP promoter. We discover that benzamide family …

RB1 controls histone H4 'Lys-20' trimethylation and inhibits the intrinsic kinase activity of TAF1. It mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase …

2015年3月11日 · Analysis of tumour samples and cell lines derived from resistant EGFR mutant patients revealed that Retinoblastoma (RB) is lost in 100% of these SCLC transformed cases, …

目的：rb1 突变和视网膜母细胞瘤 (rb) 表达缺失代表小细胞肺癌 (sclc) 的一致但并非完全不变的特征。保留野生型 rb 的 sclc 的患病率和特征尚不明确。此外，针对 rb 评估的靶向下一代测序 …

We now report that analyses of 62 SCLC tumors by immunohistochemistry (IHC) demonstrated that ~14% expressed RB1 protein, and RB1 expression was largely accompanied by …

Retinoblastoma (Rb) is a phosphoprotein that is expressed in most normal cells and acts as a tumor suppressor by providing a cell cycle checkpoint between G1 and S phases. Loss of …

2025年1月22日 · Retinoblastoma (RB) is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, …