2020年6月25日 · Reduced wall shear stress enhances RBC binding to VWF 4 and stasis increases venous thrombosis risk; however, the extent of flow reduction during venous …

In thrombosis and hemostasis, VWF is an extremely well-studied polymeric protein known for capture of flowing platelets via glycoprotein Ibα. Smeets et al. found VWF immobilized on a …

VWF binds and stabilizes FVIII (fac-tor VIII) in circulation and promotes platelet recruitment and adhesion to the endothelium. Using a flow-based system with surface-immobilized plasma and …

vWF在止血过程中主要由两种作用：①与 血小板 膜GPⅠb-Ⅸ复合物及内皮下胶原结合，介导血小板在 血管损伤 部位的黏附；②与因子Ⅷ结合，作为载体具有稳定因子Ⅷ的作用。此外，vWF …

2023年2月20日 · Von Willebrand factor (vWF) is a glycoprotein crucial to primary hemostasis through platelet and subendothelial collagen adhesion and the intrinsic coagulation cascade …

Broad expression in fat (RPKM 93.4), lung (RPKM 58.7) and 16 other tissues. 该基因编码参与止血的糖蛋白。 编码的前原蛋白在组装成大的多聚体复合物后被蛋白水解加工。 这些复合物在 …

2017年10月27日 · We find that large multimeric VWFs mainly retain their compact shape within the blood-flow core populated primarily by RBCs, and that this compact configuration …

2025年2月5日 · Despite their limitations, these models, which involve development of thrombi that share many of the hallmarks of human thrombi, have revealed important roles for von …

Von Willebrand factor (VWF) is a large multimeric glycoprotein produced in endothelial cells and megakaryocytes and present in subendothelial matrix, blood plasma and platelets. VWF …

2018年2月28日 · Force-dependent binding of platelet glycoprotein Ib (GPIb) receptors to plasma von Willebrand factor (VWF) plays a key role in hemostasis and thrombosis. Previous studies …