2024年2月6日 · In the current study, we generated and characterized new RBD-specific mAbs using the hybridoma technique that recognized linear and conformational epitopes in RBD with neutralization potency. Our mAbs are novel candidates for diagnosing and treating SARS-CoV-2.

2018年5月17日 · Telomerase is an RNA–protein complex (RNP) that extends telomeric DNA at the 3′ ends of chromosomes using its telomerase reverse transcriptase (TERT) and integral template-containing telomerase RNA (TER). Its activity is a critical determinant of human health, affecting aging, cancer, and stem cell renewal.

2020年3月31日 · 该研究解析了新冠病毒刺突蛋白受体结合结构域（receptor-binding domain，RBD）与人受体蛋白ACE2复合物2.45埃的高分辨率晶体结构，准确定位了新冠病毒RBD和受体ACE2的相互作用位点，揭示了受体ACE2特异性介导新冠病毒细胞侵染的结构基础，为治疗性抗体药物开发以及 ...

2020年2月20日，中国科学院微生物研究所在线共享了2019新型冠状病毒蛋白（s蛋白）受体结合区域（rbd）和人受体ace2复合物2.5埃分辨率晶体结构。 这是研究者首次揭示2019-CoV的S蛋白如何与受体ACE2在原子层面相互作用（微生物国家科学数据中心编号:NMDCS0000001）。

2022年2月15日 · Here we report the first landscape of the vaccine-stimulated RBD-specific antibody responses (IgG, IgA, and IgM) against the Omicron variant. We generated the map using a protein microarray, by...

2022年7月22日 · Antibodies targeting the ACE2 receptor binding motif (RBM) typically have poor breadth and are readily escaped by mutations despite high neutralization potency. Nevertheless, we characterize one potent RBM antibody (S2E12 8) with breadth across sarbecoviruses related to SARS-CoV-2 and a high barrier to viral escape.

2021年4月20日 · In this study, we examined longitudinal antibody responses (anti-RBD, anti-Spike, and inhibitory capacity against a 50% infective dose [ID 50]) among 81 people with SARS-CoV-2 infection (confirmed by nucleic acid amplification testing [NAT]) at 2 time windows—1–3 and 4–6 months following symptom onset.

The CoV-19 RBD IgG LFT by Pishtaz Teb is a rapid and reliable diagnostic tool for detecting IgG antibodies specific to the novel coronavirus. Get accurate results within minutes to support the fight against the pandemic.

2022年10月31日 · Here, we showed that dimeric S RBD -Fc and tetrameric 2xS RBD -Fc fusion proteins bind ACE2 with different affinity and block SARS-CoV-2 pseudoviral infection. Immunization of mice with S RBD -Fc fusion proteins elicited high titer of RBD-specific antibodies with robust neutralizing activity against pseudoviral infections.

2020年6月11日 · As the receptor binding domain (RBD) of the spike protein is poorly conserved between SARS-CoVs and other pathogenic human coronaviruses, the RBD represents a promising antigen for detecting CoV-specific antibodies in people.