2024年12月25日 · RBL2 (RB Transcriptional Corepressor Like 2) is a Protein Coding gene. Diseases associated with RBL2 include Brunet-Wagner Neurodevelopmental Syndrome and Retinoblastoma . Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and G0 and Early G1 .

RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling. Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been shown to interact with: Pocket protein family. RBL2 plays a crucial role in regulating the transition into cell division.

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. [5] [6] RBL2 is one of three retinoblastoma proteins encoded in the human genome (along with Rb and RBL1).

Retinoblastoma-like protein 2 is a protein in humans that is encoded by RBL2 gene. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by …

Following up a study in which interfering with the CDK2-mediated inhibitory phosphorylation of RBL2/ p130 induced apoptosis in various cancer cell lines (Pentimalli F, et al. Cancer Res. 2015; 75:LB-080), Pentimalli et al. demonstrated that RBL2/p130 is a direct substrate of AKT, a key antiapoptotic protein driving cancer cell proliferation [3].

2) 加1-2mL消化液（0.25%Trypsin-0.53mMEDTA）于培养瓶中，置于37℃培养箱中消 化1-2min，然后在显微镜下观察细胞消化情况，若细胞大部分变圆并脱落，迅速拿回

细胞描述：rbl-2h3细胞是1978年美国国立牙科研究所的免疫学实验室从 Wistar大鼠保持肿瘤状态的嗜碱性细胞中分离和克隆出来的嗜碱性白血病细胞 株。

A gene on chromosome 16q12.2 that encodes a key regulator of entry into cell division, which is directly involved in heterochromatin formation by maintaining overall chromatin structure and that of constitutive heterochromatin by stabilising histone methylation.

2018年4月2日 · Here we identified RBL2/p130 as a direct substrate of the AKT kinase, a key antiapoptotic factor hyperactive in multiple cancer types. We showed that RBL2/p130 and AKT1 physically interact and...