Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein. [5] RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase. RCC1 has been shown to interact with RANBP3 [6][7] and Ran (biology). [8][9][10][11] ^ "Human PubMed Reference:".

2024年12月25日 · RCC1 (Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Diseases associated with RCC1 include Raynaud Disease and Retinitis Pigmentosa 3. Among …

2008年8月1日 · The RCC1 superfamily of proteins is characterized by a 350–500 residue domain, known as the RCC1-like domain or RLD, that was first reported in 1987 in the Regulator of Chromosome Condensation 1, RCC1 [1], [2].

RCC1 regulates KT composition at the metaphase-anaphase transition in a Ran-GTP independent fashion through displacement of Shugoshin-1 and chromosomal passenger complex. This study provides first evidence for a mutation in RCC1 as a breast cancer susceptibility allele

2022年2月28日 · RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras homolog). RCC1 plays an essential role in the regulation of cell cycle-related activities such as nuclear envelope formation, nucl …

The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. By analyzing its amino acid sequence, RCC1 was found to consist of seven homologous repeats of 51-68 amino acid residues, which were later shown to adopt a seven-bladed beta-propell …

2022年2月22日 · RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras homolog).

2025年2月8日 · Clear-cell renal cell carcinoma (ccRCC) constitutes the majority (up to 70%) of primary RCC [1, 2, 3]. Many ccRCC patients present notable symptoms (hematuria, anemia, cachexia, and flank pain) only in advanced stages [4], making early treatment difficult.

3 天之前 · Purpose Noninvasive biomarkers for renal cell carcinoma (RCC) are vital but scarce. Kidney injury molecule-1 (KIM-1) is a transmembranous glycoprotein that is sensitive and specific to kidney injury. KIM-1 is overexpressed in RCC, and its ectodomain can be detected in blood and urine. Here, we explored whether KIM-1 is a diagnostic or prognostic indicator in RCC. Methods A comprehensive online ...

3 天之前 · Clear cell renal cell carcinoma (ccRCC), constituting approximately 70% of all adult renal cell carcinoma (RCC) cases, is the predominant histological subtype 1. Characterized by its aggressive ...