The residual dipolar coupling between two spins in a molecule occurs if the molecules in solution exhibit a partial alignment leading to an incomplete averaging of spatially anisotropic dipolar couplings.

The development of residual dipolar coupling (RDC) in protein NMR spectroscopy, over a decade ago, has become a useful and almost routine tool for accurate protein solution structure determination. RDCs provide orientation information of magnetic dipole-dipole interaction vectors within a common ref …

2024年2月16日 · Residual dipolar couplings (RDCs) are NMR measurements widely used to determine structural and dynamic information in small molecules and large macromolecules. This book provides a broad view of RDCs, from basic principles to advanced applications in organic molecules and biomolecules.

2018年12月14日 · The use of anisotropic NMR data, such as residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs), has emerged as a powerful technique for structural characterization of...

2020年6月23日 · Residual dipolar coupling (RDC), a robust anisotropic NMR parameter for structural elucidation of organic molecules, is only accessible in an anisotropic environment. Herein, we introduce a novel alignment medium based on the molecular self-assembly of oligopeptide amphiphile (OPA).

RDCs are valuable NMR observables that can be used for refinement and validation of single-domain proteins, determining the relative orientation of macromolecular complexes, supporting the resonance assignment and for elucidating protein dynamics.

Residual dipolar couplings (RDCs) have recently emerged as a new tool in nuclear magnetic resonance (NMR) with which to study macromolecular structure and function in a solution environment. RDCs are complementary to the more conventional use of NOEs to provide structural information.

Residual dipolar couplings (RDCs) have recently emerged as a new tool in nuclear magnetic resonance (NMR) with which to study macromolecular structure and function in a solution environment. RDCs are complementary to the more conventional use of NOEs to provide structural information.

2021年2月1日 · Structure determination from routinely collectable RDC data using REDCRAFT can complement existing methods to provide faster and more accurate studies of larger and more complex protein structures by NMR spectroscopy in solution state.

6 天之前 · Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for probing molecular dynamics in this time window, commonly used NMR methods for investigating μs–ms timescale dynamics include Carr–Purcell–Meiboom–Gill (CPMG) ... exchange spectroscopy (EXSY) [16], residual dipolar coupling (RDC) ...