2019年7月11日 · [68Ga]Ga-NOTA-PEG3-β-Glu-RGD2, a cyclic RGD dimer with a symmetric β-glutamate linker, was successfully designed and radiolabeled in high radiochemical yields. A series of experiments in vivo and in vitro were investigated to perform a preliminary evaluation and confirm good target at integrin αvβ3-positive tumor cells.

2009年8月31日 · Integrin α v β 3 plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence. These include vitronectin, fibronectin, fibrinogen, lamin, collagen, Von Willibrand’s factor, osteoponin, and adenovirus particles.

2007年5月5日 · In this study, we incorporated a mini-PEG spacer, 11-amino-3,6,9-trioxaundecanoic acid, with three ethylene oxide units, onto the glutamate α-amino group of the dimeric RGD peptide E [c (RGDyK)] 2 (denoted as RGD2).

2015年6月30日 · Having shown better sensitivity of RGD dimer peptide to detect the extent of atherosclerotic lesion in aortic tissues, we performed SPECT/CT imaging in the atherosclerotic model to evaluate ...

Objective: To design a new Arg-Gly-Asp (RGD) peptide that can specifically bind integrin αvβ3 and evaluate the possibility of using 131I-labeled peptide for imaging αvβ3-positive tumors. Materials and methods: The structure of the RGD monomer was selected using V-life software.

2009年3月19日 · In the present study, we labeled the new RGD dimer with PEG 4 spacers with positron-emitter 18 F, and evaluated it as a promising agent for PET imaging of tumor angiogenesis. The new RGD dimer with PEG 4 spacers (PRGD2) was linked to another PEG 4 on the glutamate α-amino group for easier labeling with 18 F.

2021年10月10日 · We recently developed 125 I- and 211 At-labeled monomer RGD peptides using a novel radiolabeling method. Both labeled peptides showed high accumulation in the tumor and exhibited similar biodistribution, demonstrating their usefulness for radiotheranostics. This study applied the …

The microPET imaging and biodistribution of the (68)Ga labeled RGD tracers were investigated in integrin alpha(v)beta(3)-positive tumor xenografts. Results: The new RGD dimers with the Gly(3) and PEG(4) linkers showed higher integrin alpha(v)beta(3) …

The mini-PEG spacered dimeric RGD peptide was labeled with 18 F through 18 F-SFB and evaluated in murine tumor models by microPET imaging. Extensive in vitro, ex vivo, and in vivo experiments were carried out to evaluate the tumor targeting efficacy and pharmacokinetics of 18 F-FPRGD2, which was compared with the previously reported 18 F-FRGD2.

2017年6月9日 · We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β 3 activity (a radiolabeled...