Introduction: G Protein-coupled Receptors and RGS Proteins
Here, we provide an overview of the role of regulator of G protein-signaling (RGS) proteins in signaling by G protein-coupled receptors (GPCRs), the latter of which represent the largest …
Regulator of G protein signaling - Wikipedia
Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that function to activate the GTPase activity of heterotrimeric G-protein α …
A Global Map of G Protein Signaling Regulation by RGS Proteins - Cell …
2020年10月1日 · Systematic analysis reveals G protein selectivity of all canonical RGS proteins. The control over the extent and timing of G protein signaling is provided by the regulator of G …
RGS家族成员在实体瘤中的功能和调控：全面综述 ... - X-MOL
2023年11月3日 · 作为一个多样化、多功能的蛋白质组，g 蛋白信号调节因子 (rgs) 家族被证明参与 gpcr 的细胞转导。越来越多的证据表明 rgs 蛋白失调是一种常见现象，并强调了这些蛋白在人 …
Function and regulation of RGS family members in solid tumours: …
2023年11月3日 · As a diverse and multifunctional group of proteins, the G protein signalling regulator (RGS) family was proven to be involved in the cellular transduction of GPCRs. …
Cell：构建出RGS蛋白调节G蛋白信号的全面图谱，有助解释为何人 …
2020年10月10日 · rgs蛋白的工作方式是让g蛋白失活，从而关闭这个信号级联反应。 这种关闭机制将G蛋白信号转导限制在一个短暂的时间窗口内，并允许细胞重置并 ...
Cell：构建出RGS蛋白调节G蛋白信号的全面图谱
2020年10月10日 · 大约在25年前被发现的rgs蛋白为一个庞大的称为g-蛋白偶联受体（gpcr）的细胞受体家族提供了重要的“制动”功能。众所周知，gpcr控制着全身细胞的数百种重要功能，并 …
Regulators of G protein signaling (RGS) Proteins as Drug Targets ...
Targeting RGS proteins presents a unique and challenging paradigm to modulate the intracellular signaling cascades initiated by an activated GPCR. The point of control can be as direct as …
Introduction: G Protein-coupled Receptors and RGS Proteins
2015年1月1日 · Here, we provide an overview of the role of regulator of G protein-signaling (RGS) proteins in signaling by G protein-coupled receptors (GPCRs), the latter of which represent the …
Structure of the class C orphan GPCR GPR158 in complex with …
2021年11月23日 · GPR158, a class C orphan GPCR, functions in cognition, stress-induced mood control, and synaptic development. Among class C GPCRs, GPR158 is unique as it lacks a …