2024年12月25日 · RHCE (Rh Blood Group CcEe Antigens) is a Protein Coding gene. Diseases associated with RHCE include Rh-Null, Amorph Type and Hemolytic Disease Of Fetus And Newborn, Rh-Induced. Among its related pathways are Blood group systems biosynthesis and Glycosaminoglycan metabolism.

Blood group Rh (CE) polypeptide is a protein that in humans is encoded by the RHCE gene. [5][6] RHCE has also recently been designated CD240CE (cluster of differentiation 240CE). The Rh blood group system is the second most clinically significant of the …

RH genes (RHD, RHCE) are highly homologous and RHAG is a close ancestral cousin. RHD codes for Rh30 proteins carrying the RhD antigen. RHCE codes for Rh30 polypeptides coexpressing the Ce, ce, cE, and CE antigens. Both genes comprise 10 exons encompassing 69kb of DNA. They reside in tandem on chromosome 1 ordered 5′-RHCE-RHD-3′ (24,35).

2025年1月7日 · The Rh blood group system is encoded by two highly homologous genes, RHD and RHCE, both with 10 exons. The RHD gene encodes one common antigen, D, while the RHCE gene encodes the main antigens C, c, E, e . Rh system is a complex and highly polymorphic blood group system causing several RH-variant alleles .

RHCE gene encodes the RhCE protein, which expresses the CcEe antigens. Rh antigens are immunogenic and antigen incompatibility can lead to hemolytic transfusion reactions and hemolytic disease of the fetus and newborn (HDFN).1 Single nucleotide variants (SNVs) in these two genes are the main cause of RH allelic variations. Six

2024年12月22日 · The RHD and RHCE genes encode the second most important blood group, Rh. The RHD gene encodes the RhD protein, which expresses the D antigen and the RHCE gene encodes the RhCE protein, which expresses the CcEe antigens.

Gene ID: 6006, updated on 8-Feb-2025. The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations.

2025年1月4日 · The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes.

The RHCE gene encodes the C/c and E/e antigens of the Rhesus (Rh) blood group system (111680). Cherif-Zahar et al. (1990) isolated cDNA clones encoding a human blood group Rh polypeptide from a human bone marrow cDNA library using a PCR amplified DNA fragment encoding the known common N-terminal region of the Rh proteins.

Rh 血型系统是临床意义第二大的血型，仅次于 ABO。 它也是血型中最具多态性的，由于缺失、基因转换和错义突变而发生变异。 Rh 血型包括在单个多肽上编码 RhC 和 RhE 抗原的基因和编码 RhD 蛋白的第二个基因。 Rh 阳性和 Rh 阴性个体的分类取决于红细胞表面是否存在高免疫原性 RhD 蛋白。 该基因的突变导致无定型 Rh-null 病。 该基因的可变剪接导致编码几种不同亚型的多个转录变体。 [RefSeq 提供，2016 年 8 月] The Rh blood group system is the second most …