The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. [6] RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE protein subunits. [7] RhAG ...

2024年12月25日 · RHD (Rh Blood Group D Antigen) is a Protein Coding gene. Diseases associated with RHD include Hemolytic Disease Of Fetus And Newborn, Rh-Induced and Blood Group, Rh System. Among its related pathways are Blood group systems biosynthesis and Glycosaminoglycan metabolism.

The RHD and RHCE genes each encode a transmembrane protein over 400 residues in length that traverses the RBC membrane 12 times. The RhD protein only differs from the common form of the RhCE protein by about 35 amino acids. The RhD protein bears the D antigen which has over 30 epitopes.

The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1.

There are now 51 antigens within the Rh system and more than 200 alleles for the RHD gene alone. RHD zygosity has been resolved, epitopes have been mapped, and many D variants with altered antigens have been identified. The relationship among the RH family members in various species contributes to our understanding of their biological importance 5.

The RHD gene arose from the duplication of an ancestral RH gene during mammalian evolution. An RHD deletion occurred 9 during the evolution of hominids, so that many modern humans completely lack the RHD gene.

Rh proteins are encoded by two separate genes located on chromosome 1; they are designated RHCE and RHD (Mouro et al, 1993). The RHCE gene encodes both the C/c and E/e proteins. The RHD gene encodes the Rh D proteins. The Rh-negative phenotype results from deletion of the RHD gene on both chromosomes. In most cases, the Rh-negative phenotype ...

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1.

HGNC Approved Gene Symbol: RHD. Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38) : 1:25,272,486-25,330,445 (from NCBI) The RHD gene encodes the Rhesus (Rh) blood group (111690) D antigen. Le Van Kim et al. (1992) cloned cDNAs representing the …