RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 inactivation suppressed microglial infiltration in the RGC layer following glaucomatous damage.

2024年10月24日 · RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 inactivation...

给予 RIP3 抑制剂 GSK872 和 RIP1 抑制剂 necrostatin-1 (Nec-1) 可防止谷氨酸诱导的 RGC 损失、视网膜损伤、神经炎症、ROS 的过度产生和 GSH 的减少。 此外，在 GSK872 和 Nec-1 抑制 RIP1/RIP3/MLKL 通路后，谷氨酸诱导的参与 NLRP3 炎性体激活的关键蛋白上调，包括 NLRP3、pro-caspase-1 ...

2007年2月15日 · In this review, we describe how RIP1 acts as a key integrator of signalling pathways initiated by stimulation of death receptors, bacterial or viral infection, genotoxic stress and T-cell...

2024年2月15日 · Ripa-56, a new kind of receptor-interacting protein kinase (RIPK) 1 inhibitor that has been found to be more potent and devoid of off-target effects compared to Necrostatin-1...

Here, we show that RIP1 is abundantly expressed in infiltrating macrophages during angiogenesis, and genetic or pharmacological inhibition of RIP1 kinase activity using kinase-inactive RIP1 K45A/K45A mice or necrostatin-1 attenuates angiogenesis in laser-induced choroidal neovascularization, Matrigel plug angiogenesis, and alkali injury-induced ...

We found that glutamate excitotoxicity induced necroptosis in RGCs through activation of the RIP1/RIP3/MLKL pathway in vivo and in vitro. Administration of the RIP3 inhibitor GSK872 and RIP1 inhibitor necrostatin-1 (Nec-1) prevented glutamate-induced RGCs loss, retinal damage, neuroinflammation, overproduction of ROS and a decrease in GSH.

2022年11月24日 · In this Perspective, considering the structure, biological functions, and disease relevance of RIP1, we summarize the recent research progress in RIP1 small-molecule inhibitor development based on different binding modalities and discuss prospective strategies for designing additional RIP1 therapeutic agents.

我们针对TNF-α诱导小鼠L929细胞的细胞坏死信号通路，利用免疫沉淀的方法纯化相关的蛋白复合物，结合Group-DIA质谱技术对相应的复合物蛋白进行鉴定及定量分析；基于得到的质谱数据，利用相关理论对相应的细胞坏死信号网络模型进行构建，系统且定量的探讨在 ...

RIP1 inhibition reduces RGC death and axonal degeneration following IRI in mice expressing OPTN-WT and OPTN-E50K variant mice. We demonstrate that RIP1 inactivation suppressed microglial infiltration in the RGC layer following glaucomatous damage.