Methylation-dependent loss of RIP3 expression in cancer ... - Nature
2015年5月8日 · RIP3 mRNA was highly expressed in the tumors of most of the 5-AD-treated mice, irrespective of whether or not mice were treated with doxorubicin (Figure 7E) and RIP3 …
TNFR信号通路系列之二：RIP家族 - 丁香园论坛 - DXY.cn
RIP3比较特别，其C端结构是RHIM，且缺少中间结构域； RIP4 和 RIP5：AD-ID。 RIP4 和 RIP5 的C端结构都是锚蛋白域（ankyrin domains，AD），但是其中间结构则是ID； RIP6 和 RIP7 …
凋亡、坏死和自噬研究，3 张信号通路图讲清关键靶点 – 王进的个 …
2021年9月15日 · 细胞坏死是一种 Caspase 非依赖性的、受调控的细胞死亡形式，由受体相互作用的丝氨酸 / 苏氨酸蛋白激酶（RIPs）和混合谱系激酶结构域样蛋白（MLKL）的激活驱动。 细 …
CaMKII is a RIP3 substrate mediating ischemia- and oxidative
2016年1月4日 · Here we show that receptor-interacting protein 3 (RIP3) triggers myocardial necroptosis, in addition to apoptosis and inflammation, through activation of Ca 2+ …
RIP3, an energy metabolism regulator that switches TNF-induced …
2009年7月17日 · By activating key enzymes of metabolic pathways, RIP3 regulates TNF-induced reactive oxygen species production, which partially accounts for RIP3's ability to promote …
The serine threonine kinase RIP3: lost and found - PMC
2015年6月6日 · Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the “programmed”, or “regulated” necrosis cell death pathway that is activated in response to …
RIP3 induces apoptosis independent of pronecrotic kinase activity
2014年11月20日 · Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three …
RIP3: a molecular switch for necrosis and inflammation - PMC
Receptor-interacting kinase 3 (RIP3) is a critical regulator of programed necrosis and is regulated by post-translation modifications. In this review, Moriwaki and Chan discuss the underlying …
RIP3, a Novel Apoptosis-inducing Kinase - ScienceDirect
1999年6月11日 · RIP3 binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor (TNF) receptor-1 signaling complex. …
催化活性: ATP + a protein = ADP + a phosphoprotein 功能: Rip3是控制坏死信号通路的关键因子。 在诱导细胞坏死时,Rip3 与Rip1 相互作用,并使其磷酸化。 Rip3通过与一些代谢酶结合刺激 …