2018年9月24日 · Live video analysis demonstrated that TLR3/4 activation of RIPK1 KO hiPSC-derived macrophages triggered TRIF and RIPK3-dependent necroptosis irrespective of caspase-8 activation.

2023年8月11日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is emerging as a critical stress sentinel that functions as a molecular switch, governing cellular survival,...

2020年12月11日 · Ripk1K612R/K612R mice are viable, but develop age-dependent reduction of RIPK1 expression, spontaneous intestinal inflammation and splenomegaly, which can be rescued by antibiotic treatment and...

2024年5月23日 · PROTAC-mediated depletion of RIPK1 deregulated TNFR1 and TLR3/4 signaling hubs, accentuating the output of NF-κB, MAPK, and IFN signaling. Additionally, RIPK1 degradation simultaneously promoted RIPK3 activation and necroptosis induction.

2022年6月14日 · In response to both stimuli, ZBP1 promotes the timely delivery of RIPK1 to the Toll-like receptor (TLR)3/4 adaptor TRIF and M1-ubiquitination of RIPK1, which sustains activation of inflammatory signaling cascades downstream of RIPK1.

The adaptor protein TRIF has a RHIM that recruits RIPK1 to TLR3 and TLR4 signaling complexes on endosomes. RIPK1 contributes to the activation of TAK1 and the IKK complex, but appears dispensable for TRIF-dependent activation of IRF3 and the expression of type I interferons, as well as TRIF-dependent activation of RIPK3/MLKL-dependent necroptosis.

RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein ...

4 天之前 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a pleiotropic mediator of cell death and inflammation that plays a key role during tumour necrosis factor receptor 1 (TNFR1) or Toll-like receptor 3 and 4 (TLR3/4) signalling.

RIPK1敲除的小鼠在出生时死于系统性炎症，RIPK3和caspase-8双敲除可以挽救小鼠的围产期死亡，Toll-like receptor 3/4 (TLR3/4)信号通路的关键调控因子Myd88或者TRIF敲除可以缓解该表型 4, 5。

2025年3月17日 · PTs expressed mainly RIPK1-PANoptosomes, which executed NET-induced PANoptosis in PTs in renal IRI model mice. Mechanistically, NET-derived double-stranded RNA (dsRNA) promoted PANoptosis in PTs, and PT-expressed TLR3 was responsible for the sensing the extracellular dsRNA.