识别胞质内RNA的蛋白家族叫做RIG-I-like receptor (RLR)。RLR在结构上拥有保守的DExH motif（在helicase domain中)，因此属于DEAD-box家族蛋白（这类蛋白含有保守的DEAD氨基酸重复序列，大多是DNA解旋酶），能够结合DNA/RNA。RLR也含有CARD结构，能够招募相应信号蛋 …

一般认为，PRR包括四类： Toll-like receptors (TLRs)、retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs)、nucleotide oligomerization domain (NOD)-like receptors (NLRs)、C-type lectin receptors (CLRs)和一系列胞内核酸感受器。 TLR是一类定位在膜上的模式识别受体，在人类中具有10种（TLR1-TLR10）在小鼠中具有12种（TLR1-TLR9，TLR11-TLR13）。

2021年8月4日 · Most PRRs in the innate immune system of vertebrates can be classified into the following five types based on protein domain homology: Toll-like receptors (TLRs), nucleotide oligomerization domain...

tlr是病原体检测中至关重要的传感器，因此识别和表征免疫细胞表面的tlr表达对于研究病毒清除的细胞机制具有重要意义。 流式细胞仪通常是分析免疫细胞TLR谱的首选方法。

In this review, we provide a concise overview of TLRs, NLRs, and RLRs: their structure, functions, signaling pathways, and regulation. We also describe various ligands for these receptors and their possible application in treatment of hematopoietic diseases.

Upon recognition of these nucleic acid species, TLRs and RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways culminating in activation of NF-kappaB, MAP kinases, and IRFs that control the transcription of genes encoding type I interferon and other inflammatory cytokines, which are important for eliminating viruses.

几类 PRRS，包括 Toll 样受体 (TLR)、NOD 样受体 (NLR) 和 RIG-I 样受体 (RLR)，可识别不同的微生物成分并直接激活免疫细胞。 TLRs是跨膜受体，而NLRs和RLRs是细胞内分子。 将免疫细胞暴露于这些受体的配体会激活细胞内信号级联反应，这些级联反应迅速诱导参与炎症和免疫反应的各种重叠和独特基因的表达。 先天免疫系统也影响参与癌症免疫监视的途径。 TLRs、NLRs 或 RLRs 的天然和合成激动剂可以在恶性细胞中引发细胞死亡，将免疫细胞（如 DC、CD8+ T 细 …

2012年5月20日 · We found here that the activation of cytosolic RIG-I-like receptors (RLRs) resulted in the selective suppression of transcription of the gene encoding the p40 subunit of interleukin 12 (Il12b) that...

2024年4月9日 · Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs).

2012年5月20日 · We found here that the activation of cytosolic RIG-I-like receptors (RLRs) resulted in the selective suppression of transcription of the gene encoding the p40 subunit of interleukin 12 (Il12b) that was effectively induced by the activation of Toll-like receptors (TLRs).